Bioinert membranes prepared from amphiphilic poly(vinyl chloride)-g-poly(oxyethylene methacrylate) graft copolymers

Rajkumar Patel; Madhumita Patel; Sung Hoon Ahn; Yong Kiel Sung; Hyung Keun Lee; Jong Hak Kim; Jung Suk Sung

doi:10.1016/j.msec.2012.12.097

Bioinert membranes prepared from amphiphilic poly(vinyl chloride)-g-poly(oxyethylene methacrylate) graft copolymers

Rajkumar Patel, Madhumita Patel, Sung Hoon Ahn, Yong Kiel Sung, Hyung Keun Lee, Jong Hak Kim, Jung Suk Sung

Department of Life Science

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Poly(vinyl chloride) (PVC) membrane was hydrophilically modified by grafting with poly(oxyethylene methacrylate) (POEM) using atom transfer radical polymerization (ATRP). The successful grafting of PVC main chain by POEM was characterized by Fourier transform infrared spectroscopy (FT-IR). The molecular weight and hydrophilicity of membranes increased with the amount of POEM grafting, as characterized by gel permeation chromatography (GPC) and contact angle measurement, respectively. Transmission electron microscope (TEM) and small angle X-ray scattering (SAXS) analysis revealed the microphase-separated structure of PVC-g-POEM and the domain spacing increased from 59.3 to 86.1 nm with increasing grafting degree. Scanning electron microscopy (SEM) was used for the direct visualization of the mouse embryonic fibroblast (MEF) cell and bacteria adhesion on the membrane surface. Protein adsorption and eukaryotic and prokaryotic cell adhesion tests showed that the bioinert properties of membranes were significantly increased with POEM content.

Original language	English
Pages (from-to)	1662-1670
Number of pages	9
Journal	Materials Science and Engineering C
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/j.msec.2012.12.097
State	Published - 1 Apr 2013

Keywords

Atom transfer radical polymerization
Cell adhesion
Graft copolymer
Membranes
Protein adsorption

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title = "Bioinert membranes prepared from amphiphilic poly(vinyl chloride)-g-poly(oxyethylene methacrylate) graft copolymers",

abstract = "Poly(vinyl chloride) (PVC) membrane was hydrophilically modified by grafting with poly(oxyethylene methacrylate) (POEM) using atom transfer radical polymerization (ATRP). The successful grafting of PVC main chain by POEM was characterized by Fourier transform infrared spectroscopy (FT-IR). The molecular weight and hydrophilicity of membranes increased with the amount of POEM grafting, as characterized by gel permeation chromatography (GPC) and contact angle measurement, respectively. Transmission electron microscope (TEM) and small angle X-ray scattering (SAXS) analysis revealed the microphase-separated structure of PVC-g-POEM and the domain spacing increased from 59.3 to 86.1 nm with increasing grafting degree. Scanning electron microscopy (SEM) was used for the direct visualization of the mouse embryonic fibroblast (MEF) cell and bacteria adhesion on the membrane surface. Protein adsorption and eukaryotic and prokaryotic cell adhesion tests showed that the bioinert properties of membranes were significantly increased with POEM content.",

keywords = "Atom transfer radical polymerization, Cell adhesion, Graft copolymer, Membranes, Protein adsorption",

author = "Rajkumar Patel and Madhumita Patel and Ahn, {Sung Hoon} and Sung, {Yong Kiel} and Lee, {Hyung Keun} and Kim, {Jong Hak} and Sung, {Jung Suk}",

year = "2013",

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doi = "10.1016/j.msec.2012.12.097",

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T1 - Bioinert membranes prepared from amphiphilic poly(vinyl chloride)-g-poly(oxyethylene methacrylate) graft copolymers

AU - Patel, Rajkumar

AU - Patel, Madhumita

AU - Ahn, Sung Hoon

AU - Sung, Yong Kiel

AU - Lee, Hyung Keun

AU - Kim, Jong Hak

AU - Sung, Jung Suk

PY - 2013/4/1

Y1 - 2013/4/1

N2 - Poly(vinyl chloride) (PVC) membrane was hydrophilically modified by grafting with poly(oxyethylene methacrylate) (POEM) using atom transfer radical polymerization (ATRP). The successful grafting of PVC main chain by POEM was characterized by Fourier transform infrared spectroscopy (FT-IR). The molecular weight and hydrophilicity of membranes increased with the amount of POEM grafting, as characterized by gel permeation chromatography (GPC) and contact angle measurement, respectively. Transmission electron microscope (TEM) and small angle X-ray scattering (SAXS) analysis revealed the microphase-separated structure of PVC-g-POEM and the domain spacing increased from 59.3 to 86.1 nm with increasing grafting degree. Scanning electron microscopy (SEM) was used for the direct visualization of the mouse embryonic fibroblast (MEF) cell and bacteria adhesion on the membrane surface. Protein adsorption and eukaryotic and prokaryotic cell adhesion tests showed that the bioinert properties of membranes were significantly increased with POEM content.

AB - Poly(vinyl chloride) (PVC) membrane was hydrophilically modified by grafting with poly(oxyethylene methacrylate) (POEM) using atom transfer radical polymerization (ATRP). The successful grafting of PVC main chain by POEM was characterized by Fourier transform infrared spectroscopy (FT-IR). The molecular weight and hydrophilicity of membranes increased with the amount of POEM grafting, as characterized by gel permeation chromatography (GPC) and contact angle measurement, respectively. Transmission electron microscope (TEM) and small angle X-ray scattering (SAXS) analysis revealed the microphase-separated structure of PVC-g-POEM and the domain spacing increased from 59.3 to 86.1 nm with increasing grafting degree. Scanning electron microscopy (SEM) was used for the direct visualization of the mouse embryonic fibroblast (MEF) cell and bacteria adhesion on the membrane surface. Protein adsorption and eukaryotic and prokaryotic cell adhesion tests showed that the bioinert properties of membranes were significantly increased with POEM content.

KW - Atom transfer radical polymerization

KW - Cell adhesion

KW - Graft copolymer

KW - Membranes

KW - Protein adsorption

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DO - 10.1016/j.msec.2012.12.097

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AN - SCOPUS:84873408958

SN - 0928-4931

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JO - Materials Science and Engineering C

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IS - 3

ER -

Bioinert membranes prepared from amphiphilic poly(vinyl chloride)-g-poly(oxyethylene methacrylate) graft copolymers

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Keywords

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