TY - JOUR
T1 - Biomimetic materials and fabrication approaches for bone tissue engineering
AU - Kim, Hwan D.
AU - Amirthalingam, Sivashanmugam
AU - Kim, Seunghyun L.
AU - Lee, Seunghun S.
AU - Rangasamy, Jayakumar
AU - Hwang, Nathaniel S.
N1 - Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2017/12/6
Y1 - 2017/12/6
N2 - Various strategies have been explored to overcome critically sized bone defects via bone tissue engineering approaches that incorporate biomimetic scaffolds. Biomimetic scaffolds may provide a novel platform for phenotypi-cally stable tissue formation and stem cell differentiation. In recent years, osteoinductive and inorganic biomimetic scaffold materials have been optimized to offer an osteo-friendly microenvironment for the osteogenic commitment of stem cells. Furthermore, scaffold structures with a micro-architecture design similar to native bone tissue are necessary for successful bone tissue regeneration. For this reason, various methods for fabricating 3D porous structures have been developed. Innovative techniques, such as 3D printing methods, are currently being utilized for optimal host stem cell infiltration, vascularization, nutrient transfer, and stem cell differentiation. In this progress report, biomimetic materials and fabrication approaches that are currently being utilized for biomimetic scaffold design are reviewed.
AB - Various strategies have been explored to overcome critically sized bone defects via bone tissue engineering approaches that incorporate biomimetic scaffolds. Biomimetic scaffolds may provide a novel platform for phenotypi-cally stable tissue formation and stem cell differentiation. In recent years, osteoinductive and inorganic biomimetic scaffold materials have been optimized to offer an osteo-friendly microenvironment for the osteogenic commitment of stem cells. Furthermore, scaffold structures with a micro-architecture design similar to native bone tissue are necessary for successful bone tissue regeneration. For this reason, various methods for fabricating 3D porous structures have been developed. Innovative techniques, such as 3D printing methods, are currently being utilized for optimal host stem cell infiltration, vascularization, nutrient transfer, and stem cell differentiation. In this progress report, biomimetic materials and fabrication approaches that are currently being utilized for biomimetic scaffold design are reviewed.
KW - 3D printing
KW - Bone tissue engineering
KW - Calcium phosphate
KW - Scaffold systems
KW - Whitlockite
UR - http://www.scopus.com/inward/record.url?scp=85035053361&partnerID=8YFLogxK
U2 - 10.1002/adhm.201700612
DO - 10.1002/adhm.201700612
M3 - Article
C2 - 29171714
AN - SCOPUS:85035053361
SN - 2192-2640
VL - 6
JO - Advanced Healthcare Materials
JF - Advanced Healthcare Materials
IS - 23
M1 - 1700612
ER -