Biomimetic materials and fabrication approaches for bone tissue engineering

Hwan D. Kim, Sivashanmugam Amirthalingam, Seunghyun L. Kim, Seunghun S. Lee, Jayakumar Rangasamy, Nathaniel S. Hwang

Research output: Contribution to journalArticlepeer-review

311 Scopus citations

Abstract

Various strategies have been explored to overcome critically sized bone defects via bone tissue engineering approaches that incorporate biomimetic scaffolds. Biomimetic scaffolds may provide a novel platform for phenotypi-cally stable tissue formation and stem cell differentiation. In recent years, osteoinductive and inorganic biomimetic scaffold materials have been optimized to offer an osteo-friendly microenvironment for the osteogenic commitment of stem cells. Furthermore, scaffold structures with a micro-architecture design similar to native bone tissue are necessary for successful bone tissue regeneration. For this reason, various methods for fabricating 3D porous structures have been developed. Innovative techniques, such as 3D printing methods, are currently being utilized for optimal host stem cell infiltration, vascularization, nutrient transfer, and stem cell differentiation. In this progress report, biomimetic materials and fabrication approaches that are currently being utilized for biomimetic scaffold design are reviewed.

Original languageEnglish
Article number1700612
JournalAdvanced Healthcare Materials
Volume6
Issue number23
DOIs
StatePublished - 6 Dec 2017

Keywords

  • 3D printing
  • Bone tissue engineering
  • Calcium phosphate
  • Scaffold systems
  • Whitlockite

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