Biopolymer film fabrication for skin mimetic tissue regenerative wound dressing applications

Logesh Kumar Sellappan, Sanmugam Anandhavelu, Mukesh Doble, Govindaraj Perumal, Ji Hoon Jeon, Dhanasekaran Vikraman, Hyun Seok Kim

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

A biopolymer film serving as a wound-healing substitute was fabricated using keratin and fibrin (extracted from a goat hoof and blood, respectively) via modified Shindai techniques. The importance of keratin and fibrin along with gelatin and mupirocin for the fabrication of a biofilm by solvent casting method is shown in this work. In vitro microscopic images of the fibroblast NIH 3T3 cell lines revealed the biocompatibility, cell viability, cell adhesion, and proliferation of biopolymer film in the wound site. The low-cost and biowaste-source-extracted keratin and fibrin blended biopolymer film supports the wound-healing process in humans.

Original languageEnglish
Pages (from-to)196-207
Number of pages12
JournalInternational Journal of Polymeric Materials and Polymeric Biomaterials
Volume71
Issue number3
DOIs
StatePublished - 2022

Keywords

  • Biopolymer
  • biowaste
  • fibrin
  • keratin
  • Teflon
  • wound dressing

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