Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: New insight into the formation of the benzoquinone moiety

Dongho Lee; Kyeong Lee; Xing Fu Cai; Nguyen Tien Dat; Shanthaveerappa K. Boovanahalli; Mijeoung Lee; Jin Chul Shin; Woncheol Kim; Jae Kap Jeong; Jong Suk Lee; Choong Hwan Lee; Jeong Hyung Lee; Young Soo Hong; Jung Joon Lee

doi:10.1002/cbic.200500441

Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: New insight into the formation of the benzoquinone moiety

Dongho Lee
, Kyeong Lee
, Xing Fu Cai
, Nguyen Tien Dat
, Shanthaveerappa K. Boovanahalli
, Mijeoung Lee
, Jin Chul Shin
, Woncheol Kim
, Jae Kap Jeong
, Jong Suk Lee
, Choong Hwan Lee
, Jeong Hyung Lee
, Young Soo Hong
, Jung Joon Lee

Department of Pharmacy

Korea Research Institute of Bioscience and Biotechnology

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

A clue towards determining the biosynthetic origin of ansamycin benzoquinone formation by spontaneous oxidation from a corresponding hydroquinone has been provided by ACDL3172 (1), a tricyclic geldanamycin derivative produced by the gel8 gene-inactivated strain of S. hygroscopicus subsp. duamyceticus JCM4427.

Original language	English
Pages (from-to)	246-248
Number of pages	3
Journal	ChemBioChem
Volume	7
Issue number	2
DOIs	https://doi.org/10.1002/cbic.200500441
State	Published - Feb 2006

Keywords

Antitumor agents
Autooxidation
Biosynthesis
Polyketides

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10.1002/cbic.200500441

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title = "Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: New insight into the formation of the benzoquinone moiety",

abstract = "A clue towards determining the biosynthetic origin of ansamycin benzoquinone formation by spontaneous oxidation from a corresponding hydroquinone has been provided by ACDL3172 (1), a tricyclic geldanamycin derivative produced by the gel8 gene-inactivated strain of S. hygroscopicus subsp. duamyceticus JCM4427.",

keywords = "Antitumor agents, Autooxidation, Biosynthesis, Polyketides",

author = "Dongho Lee and Kyeong Lee and Cai, \{Xing Fu\} and Dat, \{Nguyen Tien\} and Boovanahalli, \{Shanthaveerappa K.\} and Mijeoung Lee and Shin, \{Jin Chul\} and Woncheol Kim and Jeong, \{Jae Kap\} and Lee, \{Jong Suk\} and Lee, \{Choong Hwan\} and Lee, \{Jeong Hyung\} and Hong, \{Young Soo\} and Lee, \{Jung Joon\}",

year = "2006",

month = feb,

doi = "10.1002/cbic.200500441",

language = "English",

volume = "7",

pages = "246--248",

journal = "ChemBioChem",

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T1 - Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin

T2 - New insight into the formation of the benzoquinone moiety

AU - Lee, Dongho

AU - Lee, Kyeong

AU - Cai, Xing Fu

AU - Dat, Nguyen Tien

AU - Boovanahalli, Shanthaveerappa K.

AU - Lee, Mijeoung

AU - Shin, Jin Chul

AU - Kim, Woncheol

AU - Jeong, Jae Kap

AU - Lee, Jong Suk

AU - Lee, Choong Hwan

AU - Lee, Jeong Hyung

AU - Hong, Young Soo

AU - Lee, Jung Joon

PY - 2006/2

Y1 - 2006/2

N2 - A clue towards determining the biosynthetic origin of ansamycin benzoquinone formation by spontaneous oxidation from a corresponding hydroquinone has been provided by ACDL3172 (1), a tricyclic geldanamycin derivative produced by the gel8 gene-inactivated strain of S. hygroscopicus subsp. duamyceticus JCM4427.

AB - A clue towards determining the biosynthetic origin of ansamycin benzoquinone formation by spontaneous oxidation from a corresponding hydroquinone has been provided by ACDL3172 (1), a tricyclic geldanamycin derivative produced by the gel8 gene-inactivated strain of S. hygroscopicus subsp. duamyceticus JCM4427.

KW - Antitumor agents

KW - Autooxidation

KW - Biosynthesis

KW - Polyketides

UR - https://www.scopus.com/pages/publications/32344449220

U2 - 10.1002/cbic.200500441

DO - 10.1002/cbic.200500441

M3 - Article

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AN - SCOPUS:32344449220

SN - 1439-4227

VL - 7

SP - 246

EP - 248

JO - ChemBioChem

JF - ChemBioChem

IS - 2

ER -

Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: New insight into the formation of the benzoquinone moiety

Abstract

Keywords

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