Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: New insight into the formation of the benzoquinone moiety

  • Dongho Lee
  • , Kyeong Lee
  • , Xing Fu Cai
  • , Nguyen Tien Dat
  • , Shanthaveerappa K. Boovanahalli
  • , Mijeoung Lee
  • , Jin Chul Shin
  • , Woncheol Kim
  • , Jae Kap Jeong
  • , Jong Suk Lee
  • , Choong Hwan Lee
  • , Jeong Hyung Lee
  • , Young Soo Hong
  • , Jung Joon Lee

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

A clue towards determining the biosynthetic origin of ansamycin benzoquinone formation by spontaneous oxidation from a corresponding hydroquinone has been provided by ACDL3172 (1), a tricyclic geldanamycin derivative produced by the gel8 gene-inactivated strain of S. hygroscopicus subsp. duamyceticus JCM4427.

Original languageEnglish
Pages (from-to)246-248
Number of pages3
JournalChemBioChem
Volume7
Issue number2
DOIs
StatePublished - Feb 2006

Keywords

  • Antitumor agents
  • Autooxidation
  • Biosynthesis
  • Polyketides

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