TY - JOUR
T1 - Boron and nitrogen doped graphene quantum dots on a surface modified Cu mesh for the determination of dopamine and epinephrine
AU - Thondaiman, Pugalenthiyar
AU - Manikandan, Ramu
AU - Raj, C. Justin
AU - Savariraj, Antonysamy Dennyson
AU - Moulton, Simon E.
AU - Kim, Byung Chul
N1 - Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/8
Y1 - 2021/8
N2 - Advances in neurotransmitter detection have emerged to improve the diagnosis of mental disorders promptly and offer timely clinical treatment. However, quantifying the neurotransmitter simplifies as fast diagnosis, inexpensive operational costs, less time-consuming and miniaturized design with high configurations. Herein, amperometric detection of dopamine and epinephrine was assessed using a novel surface modified Cu mesh electrode decorated with B, N doped graphene quantum dots (B, N-GQD). The electro-polymerization PEDOT supported with B, N-GQD has been employed to fabricate modified Cu mesh to form the biosensor electrodes. The result indicated a linear steady-state response towards B, N-GQD/PEDOT/CuO modified Cu mesh electrode that exhibited a sensitivity 0.76 μA μM−1 cm−2 and a low limit of detection of 0.270 μM (S/N = 3) for the detection of dopamine. Similarly, in epinephrine detection, the B, N-GQD/PEDOT/CuO modified Cu mesh electrode revealed a high sensitivity of 2.44 μA μM−1 cm−2 and a low limit of detection of 0.084 μM (S/N = 3), respectively. Furthermore, the surface modified electrode showed excellent performance in interference and recovery test in urine samples. The surface modified Cu mesh electrode shows promise in sensing biomolecules due to the benefits of low cost and versatility for practical applications.
AB - Advances in neurotransmitter detection have emerged to improve the diagnosis of mental disorders promptly and offer timely clinical treatment. However, quantifying the neurotransmitter simplifies as fast diagnosis, inexpensive operational costs, less time-consuming and miniaturized design with high configurations. Herein, amperometric detection of dopamine and epinephrine was assessed using a novel surface modified Cu mesh electrode decorated with B, N doped graphene quantum dots (B, N-GQD). The electro-polymerization PEDOT supported with B, N-GQD has been employed to fabricate modified Cu mesh to form the biosensor electrodes. The result indicated a linear steady-state response towards B, N-GQD/PEDOT/CuO modified Cu mesh electrode that exhibited a sensitivity 0.76 μA μM−1 cm−2 and a low limit of detection of 0.270 μM (S/N = 3) for the detection of dopamine. Similarly, in epinephrine detection, the B, N-GQD/PEDOT/CuO modified Cu mesh electrode revealed a high sensitivity of 2.44 μA μM−1 cm−2 and a low limit of detection of 0.084 μM (S/N = 3), respectively. Furthermore, the surface modified electrode showed excellent performance in interference and recovery test in urine samples. The surface modified Cu mesh electrode shows promise in sensing biomolecules due to the benefits of low cost and versatility for practical applications.
KW - Cu mesh
KW - Dopamine
KW - Electrochemical biosensors
KW - Epinephrine
KW - Graphene quantum dot
UR - http://www.scopus.com/inward/record.url?scp=85107830892&partnerID=8YFLogxK
U2 - 10.1016/j.synthmet.2021.116831
DO - 10.1016/j.synthmet.2021.116831
M3 - Article
AN - SCOPUS:85107830892
SN - 0379-6779
VL - 278
JO - Synthetic Metals
JF - Synthetic Metals
M1 - 116831
ER -