TY - JOUR
T1 - BOULE, a deleted in azoospermia homolog, is recruited to stress granules in the mouse male germ cells
AU - Kim, Byunghyuk
AU - Rhee, Kunsoo
N1 - Publisher Copyright:
© 2016 Kim, Rhee. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2016/9
Y1 - 2016/9
N2 - High temperature adversely affects normal development of male germcells in mammals. Acute heat stress induces the formation of stress granules (SGs) in a set of male germ cells, and the SGs have been proposed to protect those cells from heat-induced apoptosis. DAZL, one of DAZ (Deleted in Azoospermia) family proteins, was shown to be an essential component of SGs, which is required for SG formation in the mouse testis. In the present study, we asked whether BOULE, the founding member of DAZ family proteins, is a component of the SGs.We show that BOULE is recruited to the SGs upon heat stress, and that these SGs are developmental stage-specific. These results suggest that DAZ family proteins may have conserved roles in the SGs of male germ cells.
AB - High temperature adversely affects normal development of male germcells in mammals. Acute heat stress induces the formation of stress granules (SGs) in a set of male germ cells, and the SGs have been proposed to protect those cells from heat-induced apoptosis. DAZL, one of DAZ (Deleted in Azoospermia) family proteins, was shown to be an essential component of SGs, which is required for SG formation in the mouse testis. In the present study, we asked whether BOULE, the founding member of DAZ family proteins, is a component of the SGs.We show that BOULE is recruited to the SGs upon heat stress, and that these SGs are developmental stage-specific. These results suggest that DAZ family proteins may have conserved roles in the SGs of male germ cells.
UR - http://www.scopus.com/inward/record.url?scp=84992358909&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0163015
DO - 10.1371/journal.pone.0163015
M3 - Article
C2 - 27632217
AN - SCOPUS:84992358909
SN - 1932-6203
VL - 11
JO - PLoS ONE
JF - PLoS ONE
IS - 9
M1 - e0163015
ER -