TY - JOUR
T1 - Brachial-ankle pulse wave velocity for the prediction of the presence and severity of coronary artery disease
AU - Kim, Ji Hyun
AU - Rhee, Moo Yong
AU - Kim, Yong Seok
AU - Bae, Jun Ho
AU - Nah, Deuk Young
AU - Kim, Young Kwon
AU - Lee, Myoung Mook
AU - Lim, Chiyeon
AU - Kim, Chan Joo
N1 - Publisher Copyright:
© 2014 Informa Healthcare USA, Inc.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - The predictability of brachial-ankle pulse wave velocity (baPWV) for the presence and severity of coronary artery disease (CAD) was investigated by measuring baPWV in 501 subjects scheduled for coronary angiography. Severity of CAD was measured using modified Gensini stenosis score (GSS) and classified as a vessel disease score (VDS) of 0-3. The presence of CAD was defined as diameter stenosis > 50%. Subjects were grouped in tertile by level of baPWV (<14, 14-17, >17 m/s). Subjects with CAD showed higher mean age, prevalence of men and diabetes, and systolic blood pressure. The prevalence of hypertension, use of antihypertensive medications and use of statin was not different. Subjects with CAD had higher baPWV than subjects without CAD (16.70 ± 3.46 versus 15.21 ± 3.19 m/s, p < 0.001). Multiple linear regression analysis showed significant correlation of baPWV and modified GSS (p = 0.0337). ANCOVA adjusted with age, gender, body mass index, presence of hypertension or diabetes, status of smoking, use of antihypertensive medications and risk of hypercholesterolemia showed a statistically significant association of baPWV with VDS (p < 0.0001). Highest tertile of baPWV had a statistically significant effect on the severity of CAD from an ANCOVA model. The predictive power of highest tertile of baPWV for the presence of CAD was 3.600 [95% confidence interval (CI) 1.884-6.881, p < 0.0001]. It is concluded that increased baPWV is a reliable predictor of the presence and severity of CAD, suggesting that baPWV > 17 m/s may be a threshold value for the presence and severity of CAD.
AB - The predictability of brachial-ankle pulse wave velocity (baPWV) for the presence and severity of coronary artery disease (CAD) was investigated by measuring baPWV in 501 subjects scheduled for coronary angiography. Severity of CAD was measured using modified Gensini stenosis score (GSS) and classified as a vessel disease score (VDS) of 0-3. The presence of CAD was defined as diameter stenosis > 50%. Subjects were grouped in tertile by level of baPWV (<14, 14-17, >17 m/s). Subjects with CAD showed higher mean age, prevalence of men and diabetes, and systolic blood pressure. The prevalence of hypertension, use of antihypertensive medications and use of statin was not different. Subjects with CAD had higher baPWV than subjects without CAD (16.70 ± 3.46 versus 15.21 ± 3.19 m/s, p < 0.001). Multiple linear regression analysis showed significant correlation of baPWV and modified GSS (p = 0.0337). ANCOVA adjusted with age, gender, body mass index, presence of hypertension or diabetes, status of smoking, use of antihypertensive medications and risk of hypercholesterolemia showed a statistically significant association of baPWV with VDS (p < 0.0001). Highest tertile of baPWV had a statistically significant effect on the severity of CAD from an ANCOVA model. The predictive power of highest tertile of baPWV for the presence of CAD was 3.600 [95% confidence interval (CI) 1.884-6.881, p < 0.0001]. It is concluded that increased baPWV is a reliable predictor of the presence and severity of CAD, suggesting that baPWV > 17 m/s may be a threshold value for the presence and severity of CAD.
KW - Brachial-ankle pulse wave velocity
KW - Coronary angiography
KW - Coronary artery disease
KW - Modified Gensini stenosis score
KW - Pulse wave velocity
UR - http://www.scopus.com/inward/record.url?scp=84907028687&partnerID=8YFLogxK
U2 - 10.3109/10641963.2013.846354
DO - 10.3109/10641963.2013.846354
M3 - Article
C2 - 24164335
AN - SCOPUS:84907028687
SN - 1064-1963
VL - 36
SP - 404
EP - 409
JO - Clinical and Experimental Hypertension
JF - Clinical and Experimental Hypertension
IS - 6
ER -