TY - JOUR
T1 - Brain network connectivity and association with catechol-o-methyltransferase gene polymorphism in Korean attention-deficit hyperactivity disorder children
AU - Park, Jeong Ha
AU - Son, Young Don
AU - Kim, Yeni
AU - Han, Doug Hyun
N1 - Publisher Copyright:
© 2020 Korean Neuropsychiatric Association.
PY - 2020/9
Y1 - 2020/9
N2 - Objective We sought to determine if the links between and within the default mode network (DMN) and dorsal attention network (DAT) exhibited different conditions according to catechol-O-methyltransferase (COMT) gene polymorphism in relationship to atten-tion-deficit hyperactivity disorder (ADHD) symptoms. Methods Fifty-seven children with ADHD and 48 healthy controls (HCs) were administered an intelligence test, the Children’s Depression Inventory, the Korean ADHD rating scale, and continuous performance test. Resting-state brain functional MRI scans were obtained, and COMT genotyping was performed to distinguish valine carriers and methionine homozygotes. Results Compared to controls, children with ADHD showed increased ADHD scale scores, increased visual commission errors, and increased functional connectivity (FC) within the DMN and DAT. Compared to all children with ADHD, children with the methionine homozygote and those who were valine carriers showed increased FC within the DMN and DAT and decreased FC between the DMN and DAT. FC within the DMN was also increased in HC valine carriers compared to HC children with the methionine homozygote, and in children with ADHD who were valine carriers compared to HC valine carriers. Conclusion We observed increased brain connectivity within the DMN and DAT and altered brain connectivity within and between the DMN and DAT associated with COMT polymorphism in children with ADHD. Psychiatry Investig 2020;17(9):925-933.
AB - Objective We sought to determine if the links between and within the default mode network (DMN) and dorsal attention network (DAT) exhibited different conditions according to catechol-O-methyltransferase (COMT) gene polymorphism in relationship to atten-tion-deficit hyperactivity disorder (ADHD) symptoms. Methods Fifty-seven children with ADHD and 48 healthy controls (HCs) were administered an intelligence test, the Children’s Depression Inventory, the Korean ADHD rating scale, and continuous performance test. Resting-state brain functional MRI scans were obtained, and COMT genotyping was performed to distinguish valine carriers and methionine homozygotes. Results Compared to controls, children with ADHD showed increased ADHD scale scores, increased visual commission errors, and increased functional connectivity (FC) within the DMN and DAT. Compared to all children with ADHD, children with the methionine homozygote and those who were valine carriers showed increased FC within the DMN and DAT and decreased FC between the DMN and DAT. FC within the DMN was also increased in HC valine carriers compared to HC children with the methionine homozygote, and in children with ADHD who were valine carriers compared to HC valine carriers. Conclusion We observed increased brain connectivity within the DMN and DAT and altered brain connectivity within and between the DMN and DAT associated with COMT polymorphism in children with ADHD. Psychiatry Investig 2020;17(9):925-933.
KW - Attention-deficit hyperactivity disorder
KW - Catechol-O-methyltransferase
KW - Default mode network
KW - Dorsal attention network
UR - http://www.scopus.com/inward/record.url?scp=85091068326&partnerID=8YFLogxK
U2 - 10.30773/pi.2020.0132
DO - 10.30773/pi.2020.0132
M3 - Article
AN - SCOPUS:85091068326
SN - 1738-3684
VL - 17
SP - 925
EP - 933
JO - Psychiatry Investigation
JF - Psychiatry Investigation
IS - 9
ER -