Brain-on-a-chip: A history of development and future perspective

Seokyoung Bang, Sohyeon Jeong, Nakwon Choi, Hong Nam Kim

Research output: Contribution to journalReview articlepeer-review

91 Scopus citations

Abstract

Since the advent of organ-on-a-chip, many researchers have tried to mimic the physiology of human tissue on an engineered platform. In the case of brain tissue, structural connections and cell-cell interactions are important factors for brain function. The recent development of brain-on-a-chip is an effort to mimic those structural and functional aspects of brain tissue within a miniaturized engineered platform. From this perspective, we provide an overview of trace of brain-on-a-chip development, especially in terms of complexity and high-content/high-throughput screening capabilities, and future perspectives on more in vivo-like brain-on-a-chip development.

Original languageEnglish
Article number051301
JournalBiomicrofluidics
Volume13
Issue number5
DOIs
StatePublished - 1 Sep 2019

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