TY - JOUR
T1 - Caffeine-loaded gold nanoparticles conjugated with PLA-PEG-PLA copolymer for in vitro cytotoxicity and anti-inflammatory activity
AU - Kamalakannan, Reena
AU - Mani, Gajendiran
AU - Muthusamy, Prabakaran
AU - Susaimanickam, Arul Antony
AU - Kim, Kyobum
N1 - Publisher Copyright:
© 2017 The Korean Society of Industrial and Engineering Chemistry
PY - 2017/7/25
Y1 - 2017/7/25
N2 - The purpose of the study was to develop caffeine-loaded gold nanoparticles (AuNPs) using a poly(lactic acid)-polyethylene glycol-poly(lactic acid) (PLA-PEG-PLA) polymer to enhance the anti-inflammatory activity of caffeine. Caffeine-loaded AuNPs were conjugated to PLA-PEG-PLA copolymer matrix via π-back bond between AuNPs and the ester carbonyl group of the polyester. The π-back bonded ester carbonyl oxygen strongly interacted with the caffeine molecule and exhibited enhanced anti-inflammatory activity. The physico-chemical characteristics of the resulting nanoconjugates were evaluated by a series of microscopic, diffraction, and spectroscopic methods. In vitro assays indicated increasing membrane stabilization of red blood cells and enhanced inhibition of protein denaturation.
AB - The purpose of the study was to develop caffeine-loaded gold nanoparticles (AuNPs) using a poly(lactic acid)-polyethylene glycol-poly(lactic acid) (PLA-PEG-PLA) polymer to enhance the anti-inflammatory activity of caffeine. Caffeine-loaded AuNPs were conjugated to PLA-PEG-PLA copolymer matrix via π-back bond between AuNPs and the ester carbonyl group of the polyester. The π-back bonded ester carbonyl oxygen strongly interacted with the caffeine molecule and exhibited enhanced anti-inflammatory activity. The physico-chemical characteristics of the resulting nanoconjugates were evaluated by a series of microscopic, diffraction, and spectroscopic methods. In vitro assays indicated increasing membrane stabilization of red blood cells and enhanced inhibition of protein denaturation.
KW - Anti-inflammatory activity
KW - Caffeine
KW - Gold nanoparticles
KW - In vitro cytotoxicity
KW - PLA-PEG-PLA copolymer
UR - http://www.scopus.com/inward/record.url?scp=85014804204&partnerID=8YFLogxK
U2 - 10.1016/j.jiec.2017.02.021
DO - 10.1016/j.jiec.2017.02.021
M3 - Article
AN - SCOPUS:85014804204
SN - 1226-086X
VL - 51
SP - 113
EP - 121
JO - Journal of Industrial and Engineering Chemistry
JF - Journal of Industrial and Engineering Chemistry
ER -