Caffeine-loaded gold nanoparticles conjugated with PLA-PEG-PLA copolymer for in vitro cytotoxicity and anti-inflammatory activity

Reena Kamalakannan; Gajendiran Mani; Prabakaran Muthusamy; Arul Antony Susaimanickam; Kyobum Kim

doi:10.1016/j.jiec.2017.02.021

Caffeine-loaded gold nanoparticles conjugated with PLA-PEG-PLA copolymer for in vitro cytotoxicity and anti-inflammatory activity

Reena Kamalakannan
, Gajendiran Mani
, Prabakaran Muthusamy
, Arul Antony Susaimanickam
, Kyobum Kim

Department of Chemical and Biochemical Engineering

Presidency College, Chennai
Incheon National University
Vels Institute of Science, Technology & Advanced Studies

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

The purpose of the study was to develop caffeine-loaded gold nanoparticles (AuNPs) using a poly(lactic acid)-polyethylene glycol-poly(lactic acid) (PLA-PEG-PLA) polymer to enhance the anti-inflammatory activity of caffeine. Caffeine-loaded AuNPs were conjugated to PLA-PEG-PLA copolymer matrix via π-back bond between AuNPs and the ester carbonyl group of the polyester. The π-back bonded ester carbonyl oxygen strongly interacted with the caffeine molecule and exhibited enhanced anti-inflammatory activity. The physico-chemical characteristics of the resulting nanoconjugates were evaluated by a series of microscopic, diffraction, and spectroscopic methods. In vitro assays indicated increasing membrane stabilization of red blood cells and enhanced inhibition of protein denaturation.

Original language	English
Pages (from-to)	113-121
Number of pages	9
Journal	Journal of Industrial and Engineering Chemistry
Volume	51
DOIs	https://doi.org/10.1016/j.jiec.2017.02.021
State	Published - 25 Jul 2017

Keywords

Anti-inflammatory activity
Caffeine
Gold nanoparticles
In vitro cytotoxicity
PLA-PEG-PLA copolymer

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10.1016/j.jiec.2017.02.021

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title = "Caffeine-loaded gold nanoparticles conjugated with PLA-PEG-PLA copolymer for in vitro cytotoxicity and anti-inflammatory activity",

abstract = "The purpose of the study was to develop caffeine-loaded gold nanoparticles (AuNPs) using a poly(lactic acid)-polyethylene glycol-poly(lactic acid) (PLA-PEG-PLA) polymer to enhance the anti-inflammatory activity of caffeine. Caffeine-loaded AuNPs were conjugated to PLA-PEG-PLA copolymer matrix via π-back bond between AuNPs and the ester carbonyl group of the polyester. The π-back bonded ester carbonyl oxygen strongly interacted with the caffeine molecule and exhibited enhanced anti-inflammatory activity. The physico-chemical characteristics of the resulting nanoconjugates were evaluated by a series of microscopic, diffraction, and spectroscopic methods. In vitro assays indicated increasing membrane stabilization of red blood cells and enhanced inhibition of protein denaturation.",

keywords = "Anti-inflammatory activity, Caffeine, Gold nanoparticles, In vitro cytotoxicity, PLA-PEG-PLA copolymer",

author = "Reena Kamalakannan and Gajendiran Mani and Prabakaran Muthusamy and Susaimanickam, \{Arul Antony\} and Kyobum Kim",

note = "Publisher Copyright: {\textcopyright} 2017 The Korean Society of Industrial and Engineering Chemistry",

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doi = "10.1016/j.jiec.2017.02.021",

language = "English",

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T1 - Caffeine-loaded gold nanoparticles conjugated with PLA-PEG-PLA copolymer for in vitro cytotoxicity and anti-inflammatory activity

AU - Kamalakannan, Reena

AU - Mani, Gajendiran

AU - Muthusamy, Prabakaran

AU - Susaimanickam, Arul Antony

AU - Kim, Kyobum

PY - 2017/7/25

Y1 - 2017/7/25

N2 - The purpose of the study was to develop caffeine-loaded gold nanoparticles (AuNPs) using a poly(lactic acid)-polyethylene glycol-poly(lactic acid) (PLA-PEG-PLA) polymer to enhance the anti-inflammatory activity of caffeine. Caffeine-loaded AuNPs were conjugated to PLA-PEG-PLA copolymer matrix via π-back bond between AuNPs and the ester carbonyl group of the polyester. The π-back bonded ester carbonyl oxygen strongly interacted with the caffeine molecule and exhibited enhanced anti-inflammatory activity. The physico-chemical characteristics of the resulting nanoconjugates were evaluated by a series of microscopic, diffraction, and spectroscopic methods. In vitro assays indicated increasing membrane stabilization of red blood cells and enhanced inhibition of protein denaturation.

AB - The purpose of the study was to develop caffeine-loaded gold nanoparticles (AuNPs) using a poly(lactic acid)-polyethylene glycol-poly(lactic acid) (PLA-PEG-PLA) polymer to enhance the anti-inflammatory activity of caffeine. Caffeine-loaded AuNPs were conjugated to PLA-PEG-PLA copolymer matrix via π-back bond between AuNPs and the ester carbonyl group of the polyester. The π-back bonded ester carbonyl oxygen strongly interacted with the caffeine molecule and exhibited enhanced anti-inflammatory activity. The physico-chemical characteristics of the resulting nanoconjugates were evaluated by a series of microscopic, diffraction, and spectroscopic methods. In vitro assays indicated increasing membrane stabilization of red blood cells and enhanced inhibition of protein denaturation.

KW - Anti-inflammatory activity

KW - Caffeine

KW - Gold nanoparticles

KW - In vitro cytotoxicity

KW - PLA-PEG-PLA copolymer

UR - https://www.scopus.com/pages/publications/85014804204

U2 - 10.1016/j.jiec.2017.02.021

DO - 10.1016/j.jiec.2017.02.021

M3 - Article

AN - SCOPUS:85014804204

SN - 1226-086X

VL - 51

SP - 113

EP - 121

JO - Journal of Industrial and Engineering Chemistry

JF - Journal of Industrial and Engineering Chemistry

ER -

Caffeine-loaded gold nanoparticles conjugated with PLA-PEG-PLA copolymer for in vitro cytotoxicity and anti-inflammatory activity

Abstract

Keywords

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