Caveolin-3 expression during early chicken development

Dong Hoon Shin, Jin Soo Kim, Bum Sun Kwon, Kun Sei Lee, Jong Wan Kim, Myung Ho Kim, Sa Sun Cho, Wang Jae Lee

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Caveolin-3, a protein that is correlated with caveolae, is found in muscle cells, especially during their differentiation. Although the distribution of caveolin-3 has been studied in cases such as adult and late embryonic mammalians, the expression of caveolin-3 has not been clearly defined during chicken development. In this study, we detected intense caveolin-3 immunoreactivity (IR) as early as embryonic day 4 (E4), most of the signals were localized within the neural tube and myotome. While IRs in the brain occurred in radial glia at E6, these intensities were reduced to an almost undetectable level at E8. In the case of muscle cells, the exclusive localization of caveolin-3 in the cytoplasmic membrane was detected even at E11, much earlier than in mammalian muscle tissues. Although the caveolin-3 IR pattern was similar to that reported by previous studies, we found some interesting mismatches in the case of avian tissues. Although we are unable to explain caveolin-3 expression patterns in the early embryonic stages, this study could provide a basis for further study on the function of caveolin-3 in avian embryogenesis.

Original languageEnglish
Pages (from-to)83-89
Number of pages7
JournalDevelopmental Brain Research
Volume141
Issue number1-2
DOIs
StatePublished - 14 Mar 2003

Keywords

  • Brain
  • Caveolin-3
  • Immunocytochemistry
  • Muscle
  • Neural tube

Fingerprint

Dive into the research topics of 'Caveolin-3 expression during early chicken development'. Together they form a unique fingerprint.

Cite this