TY - JOUR
T1 - Cellular toxicity of inorganic hydroxide nanoparticles
AU - Choi, Soo Jin
AU - Oh, Jae Min
AU - Park, Taeun
AU - Choy, Jin Ho
PY - 2007/11
Y1 - 2007/11
N2 - Layered double hydroxides (LDHs), anionic clays, have attracted increasing interest as nanovehicles for delivering genes, drugs, and bio-active molecules into cells. However, no attempts have been made to evaluate the potential undesirable effects of LDH nanoparticles. The cytotoxicity of LDHs with different chemical compositions (ZnAI- and MgAI-LDH) was systematically evaluated in various cell types, such as human normal cells, carcinoma cells, and red blood cells, by measuring cell viability, cell proliferation, membrane damage, and hemolytic effect. No significant cytotoxic effects could be seen in both cases, but ZnAI-LDH was determined to be slightly more toxic than MgAI-LDH in terms of membrane damage and hemolysis induction. It is, therefore, expected that LDHs could be promising candidates for novel inorganic drug delivery carriers.
AB - Layered double hydroxides (LDHs), anionic clays, have attracted increasing interest as nanovehicles for delivering genes, drugs, and bio-active molecules into cells. However, no attempts have been made to evaluate the potential undesirable effects of LDH nanoparticles. The cytotoxicity of LDHs with different chemical compositions (ZnAI- and MgAI-LDH) was systematically evaluated in various cell types, such as human normal cells, carcinoma cells, and red blood cells, by measuring cell viability, cell proliferation, membrane damage, and hemolytic effect. No significant cytotoxic effects could be seen in both cases, but ZnAI-LDH was determined to be slightly more toxic than MgAI-LDH in terms of membrane damage and hemolysis induction. It is, therefore, expected that LDHs could be promising candidates for novel inorganic drug delivery carriers.
KW - Cellular toxicity
KW - Chemical composition
KW - Hemolysis
KW - Layered double hydroxides
KW - Nanovehicles
UR - http://www.scopus.com/inward/record.url?scp=38449109597&partnerID=8YFLogxK
U2 - 10.1166/jnn.2007.085
DO - 10.1166/jnn.2007.085
M3 - Article
C2 - 18047108
AN - SCOPUS:38449109597
SN - 1533-4880
VL - 7
SP - 4017
EP - 4020
JO - Journal of Nanoscience and Nanotechnology
JF - Journal of Nanoscience and Nanotechnology
IS - 11
ER -