Cellular toxicity of inorganic hydroxide nanoparticles

Soo Jin Choi, Jae Min Oh, Taeun Park, Jin Ho Choy

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Layered double hydroxides (LDHs), anionic clays, have attracted increasing interest as nanovehicles for delivering genes, drugs, and bio-active molecules into cells. However, no attempts have been made to evaluate the potential undesirable effects of LDH nanoparticles. The cytotoxicity of LDHs with different chemical compositions (ZnAI- and MgAI-LDH) was systematically evaluated in various cell types, such as human normal cells, carcinoma cells, and red blood cells, by measuring cell viability, cell proliferation, membrane damage, and hemolytic effect. No significant cytotoxic effects could be seen in both cases, but ZnAI-LDH was determined to be slightly more toxic than MgAI-LDH in terms of membrane damage and hemolysis induction. It is, therefore, expected that LDHs could be promising candidates for novel inorganic drug delivery carriers.

Original languageEnglish
Pages (from-to)4017-4020
Number of pages4
JournalJournal of Nanoscience and Nanotechnology
Volume7
Issue number11
DOIs
StatePublished - Nov 2007

Keywords

  • Cellular toxicity
  • Chemical composition
  • Hemolysis
  • Layered double hydroxides
  • Nanovehicles

Fingerprint

Dive into the research topics of 'Cellular toxicity of inorganic hydroxide nanoparticles'. Together they form a unique fingerprint.

Cite this