TY - JOUR
T1 - Changes in the production and the effect of nitric oxide with aging in articular cartilage
T2 - An experimental study in rabbits
AU - Im, Gun Il
AU - Shin, Sung Ryong
PY - 2002
Y1 - 2002
N2 - We studied the production and the effect of nitric oxide (NO) in articular cartilage from rabbits of various ages. 40 New Zealand white rabbits in 4 age groups (1 month, 6 months, 1 year, and 3 years of age with 10 rabbits in each group) were used. Basal and induced levels of NO were lower in cultured chondrocytes from older rabbits. Exogenous NO administration suppressed the proliferative activity of chondrocytes to a greater degree in younger rabbits. Immunohistochemistry showed that older rabbits had fewer eNOS positive chondrocytes. Our findings imply that the age-related change in NO in articular cartilage does not have a relevance to increased NO production in osteoarthrosis.
AB - We studied the production and the effect of nitric oxide (NO) in articular cartilage from rabbits of various ages. 40 New Zealand white rabbits in 4 age groups (1 month, 6 months, 1 year, and 3 years of age with 10 rabbits in each group) were used. Basal and induced levels of NO were lower in cultured chondrocytes from older rabbits. Exogenous NO administration suppressed the proliferative activity of chondrocytes to a greater degree in younger rabbits. Immunohistochemistry showed that older rabbits had fewer eNOS positive chondrocytes. Our findings imply that the age-related change in NO in articular cartilage does not have a relevance to increased NO production in osteoarthrosis.
UR - http://www.scopus.com/inward/record.url?scp=0036118661&partnerID=8YFLogxK
U2 - 10.1080/000164702317281332
DO - 10.1080/000164702317281332
M3 - Article
C2 - 11928913
AN - SCOPUS:0036118661
SN - 0001-6470
VL - 73
SP - 6
EP - 10
JO - Acta Orthopaedica Scandinavica
JF - Acta Orthopaedica Scandinavica
IS - 1
ER -