Changes in tracheal respiratory mucosa after thyroidectomy: A rat model

Yun Sung Lim, Yong Jun Choi, Bo Hae Kim, Hee Bok Kim, Chang Gun Cho, Seok Won Park, Joo Hyun Park

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background/Aim: This study aimed to investigate changes in the tracheal mucosa after thyroidectomy, that can be a cause of post-thyroidectomy discomfort. Materials and Methods: Forty rats were divided into normal controls and 3 surgical groups: (i) thyroid isthmectomy with cauterization, (ii) isthmectomy by a cold instrument without hemostasis, and (iii) sham (exposure of the trachea and thyroid gland without thyroidectomy by dissection through pretracheal fascia). Animals were euthanized at 1 and 4 weeks. Mucosal edema and glandular hyperplasia were measured. Mucin production and basal cell activities were evaluated by mucin 5AC (MUC5AC) and keratin 5 (KRT5) using immunofluorescence staining. Results: Larger mucosal areas were observed in all surgical groups at 1 and 4 weeks. More submucosal glandular hyperplasia was noted in the group with isthmectomy without hemostasis. MUC5AC and KRT5 expressions were significantly higher in the surgical groups. Conclusion: The tracheal mucosa may change after surgery, which could explain postoperative discomfort after thyroidectomy.

Original languageEnglish
Pages (from-to)1133-1140
Number of pages8
JournalIn Vivo
Volume34
Issue number3
DOIs
StatePublished - Jun 2020

Keywords

  • Lymphatic system
  • Neck fascia
  • Respiratory mucosa
  • Thyroidectomy
  • Trachea

Fingerprint

Dive into the research topics of 'Changes in tracheal respiratory mucosa after thyroidectomy: A rat model'. Together they form a unique fingerprint.

Cite this