Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell Viability

Hye Min Jang, Myung Hwan Jung, Jae Sang Lee, Jun Sig Lee, In Cheol Lim, Hyunsik Im, Sang Wook Kim, Sung A. Kang, Won Je Cho, Jun Kue Park

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

We have developed chelator-free copper-64-incorporated iron oxide (IO) nanoparticle (NPs) which have both magnetic and radioactive properties being applied to positron emission tomography (PET)-magnetic resonance imaging (MRI). We have found that the IO nanoparticles composed of radioactive isotope 64Cu may act as a contrast agent being a diagnostic tool for PET as well as a good T2 MRI nanoprobe due to their good r2/r1 ratio. Furthermore, we demonstrate that the 64Cu incorporation at the core of core-shell-structured IO NPs exhibits a good in vivo stability, giving us an insightful strategy for the design of a contrast agent for the PET-MRI system.

Original languageEnglish
Article number2791
JournalNanomaterials
Volume12
Issue number16
DOIs
StatePublished - Aug 2022

Keywords

  • contrast agents
  • magnetic relaxivity
  • multimodal imaging
  • nanoparticles
  • PET-MRI
  • silica core-shell
  • superparamagnetic nanoparticles

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