Abstract
We have developed chelator-free copper-64-incorporated iron oxide (IO) nanoparticle (NPs) which have both magnetic and radioactive properties being applied to positron emission tomography (PET)-magnetic resonance imaging (MRI). We have found that the IO nanoparticles composed of radioactive isotope 64Cu may act as a contrast agent being a diagnostic tool for PET as well as a good T2 MRI nanoprobe due to their good r2/r1 ratio. Furthermore, we demonstrate that the 64Cu incorporation at the core of core-shell-structured IO NPs exhibits a good in vivo stability, giving us an insightful strategy for the design of a contrast agent for the PET-MRI system.
Original language | English |
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Article number | 2791 |
Journal | Nanomaterials |
Volume | 12 |
Issue number | 16 |
DOIs | |
State | Published - Aug 2022 |
Keywords
- contrast agents
- magnetic relaxivity
- multimodal imaging
- nanoparticles
- PET-MRI
- silica core-shell
- superparamagnetic nanoparticles