Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell Viability

Hye Min Jang; Myung Hwan Jung; Jae Sang Lee; Jun Sig Lee; In Cheol Lim; Hyunsik Im; Sang Wook Kim; Sung A. Kang; Won Je Cho; Jun Kue Park

doi:10.3390/nano12162791

Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell Viability

Hye Min Jang
, Myung Hwan Jung
, Jae Sang Lee
, Jun Sig Lee
, In Cheol Lim
, Hyunsik Im
, Sang Wook Kim
, Sung A. Kang
, Won Je Cho
, Jun Kue Park

Division of System Semiconductor

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We have developed chelator-free copper-64-incorporated iron oxide (IO) nanoparticle (NPs) which have both magnetic and radioactive properties being applied to positron emission tomography (PET)-magnetic resonance imaging (MRI). We have found that the IO nanoparticles composed of radioactive isotope ⁶⁴Cu may act as a contrast agent being a diagnostic tool for PET as well as a good T₂ MRI nanoprobe due to their good r₂/r₁ ratio. Furthermore, we demonstrate that the ⁶⁴Cu incorporation at the core of core-shell-structured IO NPs exhibits a good in vivo stability, giving us an insightful strategy for the design of a contrast agent for the PET-MRI system.

Original language	English
Article number	2791
Journal	Nanomaterials
Volume	12
Issue number	16
DOIs	https://doi.org/10.3390/nano12162791
State	Published - Aug 2022

Keywords

PET-MRI
contrast agents
magnetic relaxivity
multimodal imaging
nanoparticles
silica core-shell
superparamagnetic nanoparticles

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10.3390/nano12162791

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title = "Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell Viability",

abstract = "We have developed chelator-free copper-64-incorporated iron oxide (IO) nanoparticle (NPs) which have both magnetic and radioactive properties being applied to positron emission tomography (PET)-magnetic resonance imaging (MRI). We have found that the IO nanoparticles composed of radioactive isotope 64Cu may act as a contrast agent being a diagnostic tool for PET as well as a good T2 MRI nanoprobe due to their good r2/r1 ratio. Furthermore, we demonstrate that the 64Cu incorporation at the core of core-shell-structured IO NPs exhibits a good in vivo stability, giving us an insightful strategy for the design of a contrast agent for the PET-MRI system.",

keywords = "PET-MRI, contrast agents, magnetic relaxivity, multimodal imaging, nanoparticles, silica core-shell, superparamagnetic nanoparticles",

author = "Jang, \{Hye Min\} and Jung, \{Myung Hwan\} and Lee, \{Jae Sang\} and Lee, \{Jun Sig\} and Lim, \{In Cheol\} and Hyunsik Im and Kim, \{Sang Wook\} and Kang, \{Sung A.\} and Cho, \{Won Je\} and Park, \{Jun Kue\}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = aug,

doi = "10.3390/nano12162791",

language = "English",

volume = "12",

journal = "Nanomaterials",

issn = "2079-4991",

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T1 - Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging

T2 - Improved Radiocopper Stability and Cell Viability

AU - Jang, Hye Min

AU - Jung, Myung Hwan

AU - Lee, Jae Sang

AU - Lee, Jun Sig

AU - Lim, In Cheol

AU - Im, Hyunsik

AU - Kim, Sang Wook

AU - Kang, Sung A.

AU - Cho, Won Je

AU - Park, Jun Kue

PY - 2022/8

Y1 - 2022/8

N2 - We have developed chelator-free copper-64-incorporated iron oxide (IO) nanoparticle (NPs) which have both magnetic and radioactive properties being applied to positron emission tomography (PET)-magnetic resonance imaging (MRI). We have found that the IO nanoparticles composed of radioactive isotope 64Cu may act as a contrast agent being a diagnostic tool for PET as well as a good T2 MRI nanoprobe due to their good r2/r1 ratio. Furthermore, we demonstrate that the 64Cu incorporation at the core of core-shell-structured IO NPs exhibits a good in vivo stability, giving us an insightful strategy for the design of a contrast agent for the PET-MRI system.

AB - We have developed chelator-free copper-64-incorporated iron oxide (IO) nanoparticle (NPs) which have both magnetic and radioactive properties being applied to positron emission tomography (PET)-magnetic resonance imaging (MRI). We have found that the IO nanoparticles composed of radioactive isotope 64Cu may act as a contrast agent being a diagnostic tool for PET as well as a good T2 MRI nanoprobe due to their good r2/r1 ratio. Furthermore, we demonstrate that the 64Cu incorporation at the core of core-shell-structured IO NPs exhibits a good in vivo stability, giving us an insightful strategy for the design of a contrast agent for the PET-MRI system.

KW - PET-MRI

KW - contrast agents

KW - magnetic relaxivity

KW - multimodal imaging

KW - nanoparticles

KW - silica core-shell

KW - superparamagnetic nanoparticles

UR - https://www.scopus.com/pages/publications/85137414004

U2 - 10.3390/nano12162791

DO - 10.3390/nano12162791

M3 - Article

AN - SCOPUS:85137414004

SN - 2079-4991

VL - 12

JO - Nanomaterials

JF - Nanomaterials

IS - 16

M1 - 2791

ER -

Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell Viability

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Keywords

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