Chemically or surgically induced thyroid dysfunction altered gut microbiota in rat models

Na Rae Shin, Shambhunath Bose, Jing Hua Wang, Young Do Nam, Eun Ji Song, Dong Woo Lim, Hee Bok Kim, Yun Sung Lim, Han Seok Choi, Hojun Kim

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Thyroid hormones are essential for the regulation of energy homeostasis and metabolic processes. However, the relationship between thyroid function and host gut microbial communities is not properly understood. To determine whether and how gut microbiota is associated with thyroid function, metagenomics analysis of the bacterial population in fecal samples of rat models of hyperthyroidism (induced by levothyroxine) and hypothyroidism (induced by propylthiouracil or thyroidectomy) was conducted through 16S rRNA gene sequencing. Our results revealed that all thyroid dysfunction models were definitely established and gut microbial composition varied according to different thyroid functional status. The relative abundance of Ruminococcus was significantly higher in the hyperthyroidism group (HE) vs both the normal and hypothyroidism groups (HO) while S24-7 was significantly higher in the HO group. The population of Prevotellaceae and Prevotella were significantly lower in the HO group vs the normal. Firmicutes and Oscillospira were significantly higher in the SHO (surgery-induced hypothyroidism) group, while Prevotellaceae and Prevotella showed lower abundance in the SHO group than the SHAM group. Present results suggest that thyroid functions may have the potential to influence the profile of gut microbiota and could be used as foundation to investigate interaction mechanism between thyroid and gut microbiome.

Original languageEnglish
Pages (from-to)8686-8701
Number of pages16
JournalFASEB Journal
Volume34
Issue number6
DOIs
StatePublished - 1 Jun 2020

Keywords

  • gut microbiota
  • hyperthyroidism
  • hypothyroidism
  • thyroid function
  • thyroidectomy

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