Chondrogenic and osteogenic induction from iPS cells

Ji Yun Ko, Gun II Im

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Scopus citations

Abstract

Articular cartilage (AC) does not heal spontaneously when injured in adults. This incapacity for self-repair after damage ultimately leads to the development of osteoarthritis. In contrast, bone repairs itself without scarring. However, complete bone healing fails to occur in large defects coming from major trauma or malignant tumor resection. Cell therapy has been investigated for these musculoskeletal conditions. Induced pluripotent stem cells (iPSCs) possess the characteristics of embryonic stem cells (ESCs) in potentially unlimited proliferation while avoiding the ethical controversies. However, several issues need to be resolved before iPSCs can be considered as a potential therapeutic measure for cartilage and bone regeneration. The authors developed protocol to examine the in vitro chondrogenesis and osteogenesis from hiPSCs and in vivo cartilage and bone regeneration using animal models.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages441-450
Number of pages10
DOIs
StatePublished - 1 Jan 2016

Publication series

NameMethods in Molecular Biology
Volume1357
ISSN (Print)1064-3745

Keywords

  • Cell therapy
  • Chondrogenesis
  • Induced pluripotent stem cells
  • Osteogenesis
  • Regeneration

Fingerprint

Dive into the research topics of 'Chondrogenic and osteogenic induction from iPS cells'. Together they form a unique fingerprint.

Cite this