Clinical effectiveness of house dust mite immunotherapy in mono-versus poly-sensitised patients with allergic rhinitis: A systematic review and meta-analysis*

Jin Youp Kim, Doyeon Hwang, Myoung Jin Jang, Chae Seo Rhee, Doo Hee Han

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Selecting an appropriate allergen-specific immunotherapy (AIT) regimen for polysensitised allergic rhinitis (AR) patients is challenging for clinicians. Although previous studies showed comparable effectiveness of single-allergen AIT with house dust mite (HDM) extract between monosensitised and polysensitised AR patients, there is no systematic review and meta-analysis demonstrating the comparable effectiveness of HDM AIT. In this meta-analysis, we analysed nine studies to compare the clinical effectiveness of HDM AIT. The primary outcome was nasal symptom score and secondary outcomes were medication and quality of life scores. The changes in nasal symptom score after HDM AIT did not significantly differ between monosensitised and polysensitised patients. The clinical effectiveness of HDM AIT regarding medication and quality of life score was not significantly different between monosensitised and polysensitised patients). In conclusion, single-allergen AIT with HDM extract showed comparable clinical effectiveness between polysensitised and monosensitised patients with AR.

Original languageEnglish
Pages (from-to)352-359
Number of pages8
JournalRhinology
Volume59
Issue number4
DOIs
StatePublished - 2021

Keywords

  • Allergen immunotherapy
  • Allergic rhinitis
  • House dust mites
  • Immunologic desensitisation
  • Meta-analysis

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