Clinicoprognostic Study of Hydroa Vacciniforme-like Lymphoproliferative Diseases: A Systematic Review

Young Jae Kim; Hee Joo Yang; Chong Hyun Won; Sung Eun Chang; Mi Woo Lee; Woo Jin Lee

doi:10.1159/000530607

Clinicoprognostic Study of Hydroa Vacciniforme-like Lymphoproliferative Diseases: A Systematic Review

Young Jae Kim, Hee Joo Yang, Chong Hyun Won, Sung Eun Chang, Mi Woo Lee, Woo Jin Lee

Department of Medicine

University of Ulsan

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: Limited clinicopathological and prognostic data are available on hydroa vacciniforme (HV)-like lymphoproliferative diseases (HVLPD). Methods: This systematic review searched HVLPD reports in Medline via PubMed, Embase, Cochrane, and CINAHL databases in October 2020. Results: A total of 393 patients (65 classic HV, 328 severe HV/HV-like T-cell lymphoma [HVLL]) were analyzed. Among severe HV/HVLL cases, 56.0% were Asians, whereas 3.1% were Caucasians. Facial edema, hypersensitivity to mosquito bites, the onset of skin lesion, and percentage of severe HV/HVLL differed significantly by race. Progression to systemic lymphoma was confirmed in 9.4% of HVLPD patients. Death occurred in 39.7% patients with severe HV/HVLL. Facial edema was the only risk factor associated with progression and overall survival. Mortality risk was higher in Latin Americans than in Asians and Caucasians. CD4/CD8 double-negativity was significantly associated with the worst prognosis and increased mortality. Conclusion: HVLPD is a heterogeneous entity with variable clinicopathological features associated with genetic predispositions.

Original language	English
Pages (from-to)	700-711
Number of pages	12
Journal	Dermatology
Volume	239
Issue number	5
DOIs	https://doi.org/10.1159/000530607
State	Published - 1 Oct 2023

Keywords

Hydroa vacciniforme-like lymphoproliferative diseases
Lymphoma
Photodermatoses
Prognosis
Systematic review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1159/000530607

Cite this

@article{d2fdce640136426aac7f620297f597b1,

title = "Clinicoprognostic Study of Hydroa Vacciniforme-like Lymphoproliferative Diseases: A Systematic Review",

abstract = "Background: Limited clinicopathological and prognostic data are available on hydroa vacciniforme (HV)-like lymphoproliferative diseases (HVLPD). Methods: This systematic review searched HVLPD reports in Medline via PubMed, Embase, Cochrane, and CINAHL databases in October 2020. Results: A total of 393 patients (65 classic HV, 328 severe HV/HV-like T-cell lymphoma [HVLL]) were analyzed. Among severe HV/HVLL cases, 56.0% were Asians, whereas 3.1% were Caucasians. Facial edema, hypersensitivity to mosquito bites, the onset of skin lesion, and percentage of severe HV/HVLL differed significantly by race. Progression to systemic lymphoma was confirmed in 9.4% of HVLPD patients. Death occurred in 39.7% patients with severe HV/HVLL. Facial edema was the only risk factor associated with progression and overall survival. Mortality risk was higher in Latin Americans than in Asians and Caucasians. CD4/CD8 double-negativity was significantly associated with the worst prognosis and increased mortality. Conclusion: HVLPD is a heterogeneous entity with variable clinicopathological features associated with genetic predispositions.",

keywords = "Hydroa vacciniforme-like lymphoproliferative diseases, Lymphoma, Photodermatoses, Prognosis, Systematic review",

author = "Kim, {Young Jae} and Yang, {Hee Joo} and Won, {Chong Hyun} and Chang, {Sung Eun} and Lee, {Mi Woo} and Lee, {Woo Jin}",

note = "Publisher Copyright: {\textcopyright} 2023 S. Karger AG, Basel ",

year = "2023",

month = oct,

day = "1",

doi = "10.1159/000530607",

language = "English",

volume = "239",

pages = "700--711",

journal = "Dermatology",

issn = "1018-8665",

publisher = "S. Karger AG",

number = "5",

}

TY - JOUR

T1 - Clinicoprognostic Study of Hydroa Vacciniforme-like Lymphoproliferative Diseases

T2 - A Systematic Review

AU - Kim, Young Jae

AU - Yang, Hee Joo

AU - Won, Chong Hyun

AU - Chang, Sung Eun

AU - Lee, Mi Woo

AU - Lee, Woo Jin

PY - 2023/10/1

Y1 - 2023/10/1

N2 - Background: Limited clinicopathological and prognostic data are available on hydroa vacciniforme (HV)-like lymphoproliferative diseases (HVLPD). Methods: This systematic review searched HVLPD reports in Medline via PubMed, Embase, Cochrane, and CINAHL databases in October 2020. Results: A total of 393 patients (65 classic HV, 328 severe HV/HV-like T-cell lymphoma [HVLL]) were analyzed. Among severe HV/HVLL cases, 56.0% were Asians, whereas 3.1% were Caucasians. Facial edema, hypersensitivity to mosquito bites, the onset of skin lesion, and percentage of severe HV/HVLL differed significantly by race. Progression to systemic lymphoma was confirmed in 9.4% of HVLPD patients. Death occurred in 39.7% patients with severe HV/HVLL. Facial edema was the only risk factor associated with progression and overall survival. Mortality risk was higher in Latin Americans than in Asians and Caucasians. CD4/CD8 double-negativity was significantly associated with the worst prognosis and increased mortality. Conclusion: HVLPD is a heterogeneous entity with variable clinicopathological features associated with genetic predispositions.

AB - Background: Limited clinicopathological and prognostic data are available on hydroa vacciniforme (HV)-like lymphoproliferative diseases (HVLPD). Methods: This systematic review searched HVLPD reports in Medline via PubMed, Embase, Cochrane, and CINAHL databases in October 2020. Results: A total of 393 patients (65 classic HV, 328 severe HV/HV-like T-cell lymphoma [HVLL]) were analyzed. Among severe HV/HVLL cases, 56.0% were Asians, whereas 3.1% were Caucasians. Facial edema, hypersensitivity to mosquito bites, the onset of skin lesion, and percentage of severe HV/HVLL differed significantly by race. Progression to systemic lymphoma was confirmed in 9.4% of HVLPD patients. Death occurred in 39.7% patients with severe HV/HVLL. Facial edema was the only risk factor associated with progression and overall survival. Mortality risk was higher in Latin Americans than in Asians and Caucasians. CD4/CD8 double-negativity was significantly associated with the worst prognosis and increased mortality. Conclusion: HVLPD is a heterogeneous entity with variable clinicopathological features associated with genetic predispositions.

KW - Hydroa vacciniforme-like lymphoproliferative diseases

KW - Lymphoma

KW - Photodermatoses

KW - Prognosis

KW - Systematic review

UR - http://www.scopus.com/inward/record.url?scp=85174752595&partnerID=8YFLogxK

U2 - 10.1159/000530607

DO - 10.1159/000530607

M3 - Article

C2 - 37231869

AN - SCOPUS:85174752595

SN - 1018-8665

VL - 239

SP - 700

EP - 711

JO - Dermatology

JF - Dermatology

IS - 5

ER -

Clinicoprognostic Study of Hydroa Vacciniforme-like Lymphoproliferative Diseases: A Systematic Review

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this