Abstract
A facile and efficient method for Cp*CoIII-catalyzed C(sp2)–H bond alkylation was developed using 2-aryl pyridines and unactivated alkenes. The reaction proceeded atom-economically with readily available styrene derivatives and an abundant cobalt catalyst. This reaction tolerates a broad range of functional groups, directing groups, styrenes and affords mono-diarylethane products with high linear selectivity. To demonstrate the synthetic utility and the potential application in organic synthesis, a gram-scale reaction and further C–H bond functionalizations of the mono-alkylated product were performed.
Original language | English |
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Pages (from-to) | 4026-4030 |
Number of pages | 5 |
Journal | European Journal of Organic Chemistry |
Volume | 2020 |
Issue number | 26 |
DOIs | |
State | Published - 15 Jul 2020 |
Keywords
- Co(III)-catalyst
- C–H alkylation
- Phenylethyl group
- Unactivated alkenes