Cobalt-Catalyzed Direct C(sp2)–H Alkylation with Unactivated Alkenes

Ye Lim Kim, Sun a. Park, Ju Hyun Kim

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A facile and efficient method for Cp*CoIII-catalyzed C(sp2)–H bond alkylation was developed using 2-aryl pyridines and unactivated alkenes. The reaction proceeded atom-economically with readily available styrene derivatives and an abundant cobalt catalyst. This reaction tolerates a broad range of functional groups, directing groups, styrenes and affords mono-diarylethane products with high linear selectivity. To demonstrate the synthetic utility and the potential application in organic synthesis, a gram-scale reaction and further C–H bond functionalizations of the mono-alkylated product were performed.

Original languageEnglish
Pages (from-to)4026-4030
Number of pages5
JournalEuropean Journal of Organic Chemistry
Volume2020
Issue number26
DOIs
StatePublished - 15 Jul 2020

Keywords

  • Co(III)-catalyst
  • C–H alkylation
  • Phenylethyl group
  • Unactivated alkenes

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