Combinatorial nanodiamond in pharmaceutical and biomedical applications

Dae Gon Lim, Racelly Ena Prim, Ki Hyun Kim, Eunah Kang, Kinam Park, Seong Hoon Jeong

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

One of the newly emerging carbon materials, nanodiamond (ND), has been exploited for use in traditional electric materials and this has extended into biomedical and pharmaceutical applications. Recently, NDs have attained significant interests as a multifunctional and combinational drug delivery system. ND studies have provided insights into granting new potentials with their wide ranging surface chemistry, complex formation with biopolymers, and combination with biomolecules. The studies that have proved ND inertness, biocompatibility, and low toxicity have made NDs much more feasible for use in real in vivo applications. This review gives an understanding of NDs in biomedical engineering and pharmaceuticals, focusing on the classified introduction of ND/drug complexes. In addition, the diverse potential applications that can be obtained with chemical modification are presented.

Original languageEnglish
Pages (from-to)41-51
Number of pages11
JournalInternational Journal of Pharmaceutics
Volume514
Issue number1
DOIs
StatePublished - 30 Nov 2016

Keywords

  • Complex formation
  • Drug delivery
  • Nanodiamond
  • Surface

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