Combined repeated-dose toxicity study of silver nanoparticles with the reproduction/developmental toxicity screening test

Jeong Sup Hong, Suhyon Kim, Sang Hee Lee, Eunhye Jo, Byungcheun Lee, Junheon Yoon, Ig Chun Eom, Hyun Mi Kim, Pilje Kim, Kyunghee Choi, Moo Yeol Lee, Yeong Rok Seo, Younghun Kim, Yeonjin Lee, Jonghye Choi, Kwangsik Park

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Combined repeated-dose toxicity study of citrate-capped silver nanoparticles (7.9 ± 0.95 nm) with reproduction/developmental toxicity was investigated in rats orally treated with 62.5, 125 and 250 mg/kg, once a day for 42 days for males and up to 52 days for females. The test was performed based on the Organization for Economic Cooperation and Development test guideline 422 and Good Laboratory Practice principles. No death was observed in any of the groups. Alopecia, salivation and yellow discolouration of the lung were observed in a few rats but the symptoms were not dose-dependent. Haematology, serum biochemical investigation and histopathological analysis revealed no statistically significant differences between control group and the treated groups. Toxicity endpoints of reproduction/developmental screening test including mating, fertility, implantation, delivery and foetus were measured. There was no evidence of toxicity.

Original languageEnglish
Pages (from-to)349-362
Number of pages14
JournalNanotoxicology
Volume8
Issue number4
DOIs
StatePublished - Jun 2014

Keywords

  • Rats
  • Repeated-dose toxicity
  • Reproduction/developmental toxicity
  • Screening test
  • Silver nanoparticles

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