Comparison of cytological and histological preparations in the diagnosis of pancreatic malignancies using endoscopic ultrasound-guided fine needle aspiration

Dong Kee Jang, Sang Hyub Lee, Jun Kyu Lee, Woo Hyun Paik, Kwang Hyun Chung, Ban Seok Lee, Jun Hyuk Son, Jae Woo Lee, Ji Kon Ryu, Yong Tae Kim, Kyoung Bun Lee

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) has become a crucial diagnostic technique for pancreatic malignancies. The specimen obtained by EUS-FNA can be prepared for either cytological or histological examinations. This study was to compare diagnostic performance of cytological and histological preparations using EUS-FNA in the same lesions when pancreatic malignancies were suspected. Methods One hundred and eighteen patients who underwent EUS-FNA for suspected pancreatic malignancies were consecutively enrolled. All procedures were conducted by a single echoendoscopist under the same conditions. Four adequate preparations were obtained by 22-gauge needles with 20 to-and-fro movements for each pass. The 4 preparations included 2 cytological and 2 histological specimens. The pathologic reviews of all specimens were conducted independently by a single experienced cytopathologist. Sensitivity, specificity, and accuracy of the 2 preparations were compared. Results The enrolled patients consisted of 62 males (52.5%), with the mean age of 64.6±10.5 years. Surgery was performed in 23 (19.5%) patients. One hundred and sixteen (98.3%) lesions were classified as malignant, while 2 (1.7%) were benign. Sensitivity of cytology and histology were 87.9% and 81.9%, respectively, with no significant difference (P=0.190). Accuracy was also not significantly different. Cytological preparation was more sensitive when the size of lesion was <3 cm (86.7% vs 68.9%, P=0.033). Conclusions Our results suggested that the diagnostic performances of cytological and histological preparations are not significantly different for the diagnosis of pancreatic malignancies. However, cytological preparation might be more sensitive for pancreatic lesions <3 cm.

Original languageEnglish
Pages (from-to)418-423
Number of pages6
JournalHepatobiliary and Pancreatic Diseases International
Volume16
Issue number4
DOIs
StatePublished - 15 Aug 2017

Keywords

  • cytology
  • endoscopic ultrasound-guided fine needle aspiration
  • histology
  • pancreatic neoplasms
  • pathology

Fingerprint

Dive into the research topics of 'Comparison of cytological and histological preparations in the diagnosis of pancreatic malignancies using endoscopic ultrasound-guided fine needle aspiration'. Together they form a unique fingerprint.

Cite this