Comparison of epidermal/dermal damage between the long-pulsed 1064nm Nd:YAG and 755nm alexandrite lasers under relatively high fluence conditions: Quantitative and histological assessments

Ju Hwan Lee, So Ra Park, Jeong Ho Jo, Sung Yun Park, Young Kwon Seo, Sung Min Kim

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Objective: The purpose of this study was to compare degrees of epidermal/dermal tissue damage quantitatively and histologically after laser irradiation, to find ideal treatment conditions with relatively high fluence for skin rejuvenation. Background data: A number of recent studies have evaluated the clinical efficacy and safety of therapeutic lasers under relatively low fluence conditions. Methods: We transmitted the long-pulsed 1064nm Nd:YAG and 755nm Alexandrite lasers into pig skin according to different fluences and spot diameters, and estimated epidermal/dermal temperatures. Pig skin specimens were stained with hematoxylin and eosin for histological assessments. The fluence conditions comprised 26, 30, and 36J/cm2, and the spot diameter conditions were 5, 8, and 10mm. Pulse duration was 30ms for all experiments. Results: Both lasers produced reliable thermal damage on the dermis without any serious epidermal injuries, under relatively high fluence conditions. The 1064nm laser provided more active fibrous formations than the 755nm laser, while higher risks for tissue damages simultaneously occurred. Conclusions: The ideal treatment conditions for skin rejuvenation were 8mm diameter with 30J/cm 2 and 10mm diameter with 26J/cm2 for the 1064nm laser, and 8mm diameter with 36J/cm2 and 10mm diameter with 26J/cm2 for the 755nm laser.

Original languageEnglish
Pages (from-to)386-393
Number of pages8
JournalPhotomedicine and Laser Surgery
Volume32
Issue number7
DOIs
StatePublished - 1 Jul 2014

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