Comparison of fentanyl versus meperidine in combination with midazolam for sedative colonoscopy in Korea

Gwan Woo Hong, Jun Kyu Lee, Jung Hyeon Lee, Ji Hun Bong, Sung Hun Choi, Hyeki Cho, Ji Hyung Nam, Dong Kee Jang, Hyoun Woo Kang, Jae Hak Kim, Yun Jeong Lim, Moon Soo Koh, Jin Ho Lee

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background/Aims: Combination of midazolam and opioids is used widely for endoscopic sedation. Compared with meperidine, fentanyl is reportedly associated with rapid recovery, turnover rate of endoscopy room, and quality of endoscopy. We compared fentanyl with meperidine when combined with midazolam for sedative colonoscopy. Methods: A retrospective, cross-sectional, 1:2 matching study was conducted. Induction and recovery time were compared as the primary outcomes. Moreover, cecal intubation time, withdrawal time, total procedure time of colonoscopy, paradoxical reaction, adenoma detection rate, and adverse effect of midazolam or opioids were assessed as the secondary outcomes. Results: A total of 129 subjects (43 fentanyl vs. 86 meperidine) were included in the analysis. The fentanyl group showed significantly more rapid induction time (4.5±2.7 min vs. 7.5±4.7 min, p<0.001), but longer recovery time (59.5±25.6 min vs. 50.3±10.9 min, p=0.030) than the meperidine group. In multivariate analysis, the induction time of the fentanyl group was 3.40 min faster (p<0.001), but the recovery time was 6.38 min longer (p=0.046) than that of the meperidine group. There was no difference in withdrawal time and adenoma detection rate between the two groups. Conclusions: The fentanyl group had more rapid sedation induction time but longer recovery time than the meperidine group.

Original languageEnglish
Pages (from-to)562-567
Number of pages6
JournalClinical Endoscopy
Volume53
Issue number5
DOIs
StatePublished - 2020

Keywords

  • Colonoscopy
  • Fentanyl
  • Meperidine
  • Midazolam
  • Sedation

Fingerprint

Dive into the research topics of 'Comparison of fentanyl versus meperidine in combination with midazolam for sedative colonoscopy in Korea'. Together they form a unique fingerprint.

Cite this