Comparison of immune response by virus infection and vaccination to 2009 pandemic influenza A/H1N1 in children

Eun Kyeong Kang, Jung Sub Lim, Jun Ah Lee, Dong Ho Kim

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

We aimed to compare the immune response induced by natural infection with 2009 pandemic influenza A/H1N1 (pH1N1) virus and by monovalent pH1N1 vaccination in children and adolescents. This cross-sectional clinical study was conducted at 3 hospitals in Korea from February to May 2010. A total of 266 healthy subjects aged from 6 months to 18 yr were tested for the presence of the antibody against pH1N1 using hemagglutination inhibition (HI) test. Information about pH1N1 vaccination and laboratory-confirmed pH1N1 infection history was obtained. The overall rate of HI titers of ≥ 1:40 against pH1N1 was 38.7%, and the geometric mean titer (GMT) was 20.5. Immunogenicity of pH1N1 vaccination only was reflected by a 41.1% of seroprotection rate and a GMT of 22.5. Immunogenicity of natural infection only was reflected by a 61.0% of seroprotection rate and a GMT of 40.0. GMT was significantly higher in the subjects of natural infection group than in the subjects of pH1N1 vaccination group (P < 0.001). The immune responses induced by natural pH1N1 infection exceed those induced by pH1N1 vaccinations.

Original languageEnglish
Pages (from-to)274-279
Number of pages6
JournalJournal of Korean Medical Science
Volume28
Issue number2
DOIs
StatePublished - 2013

Keywords

  • Child
  • Immune response
  • Natural infection
  • Pandemic influenza A
  • Vaccination

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