Comparison of the clinical characteristics and outcomes of Klebsiella pneumoniae and Streptococcus pneumoniae meningitis

Jiwon Jung, Ki Ho Park, Seong Yeon Park, Eun Hee Song, Eun Jung Lee, Seong Ho Choi, Eun Ju Choo, Yee Gyung Kwak, Heungsup Sung, Sung Han Kim, Sang Oh Lee, Mi Na Kim, Yang Soo Kim, Jun Hee Woo, Sang Ho Choi

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

This multicenter, retrospective cohort study compared the clinical characteristics and outcomes of community-acquired Klebsiella pneumoniae meningitis (CA-KPM) with those of community-acquired Streptococcus pneumoniae meningitis (CA-SPM). Eighty-three adult patients, 27 with CA-KPM and 56 with CA-SPM, were included. Diabetes mellitus (48.1% versus 21.4%; P = 0.01) and liver cirrhosis (22.2% versus 5.4%; P = 0.05) were more commonly associated with CA-KPM. Comatose mental status (40.7% versus 12.5%; P = 0.01), septic shock (44.4% versus 8.9%; P<. 0.001), and concomitant extrameningeal infections (40.7% versus 7.1%; P = 0.001) were also more common in the CA-KPM group. The 28-day mortality (44.4% versus 10.7%; P<. 0.001) and inhospital mortality (51.9% versus 14.3%; P<. 0.001) were higher in the CA-KPM group. In conclusion, diabetes mellitus and liver cirrhosis are more common in the CA-KPM patients who were also more likely to present with severe manifestations and poor outcomes.

Original languageEnglish
Pages (from-to)87-91
Number of pages5
JournalDiagnostic Microbiology and Infectious Disease
Volume82
Issue number1
DOIs
StatePublished - 1 May 2015

Keywords

  • Klebsiella pneumoniae
  • Meningitis
  • Streptococcus pneumoniae

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