Comprehensive assessment of the estrogenic activity of resin composites

Hyeyeong Seo, Yu Jin Ahn, Huiwon Seo, Ahreum Seo, Hayeon Lee, Seok Hee Lee, Won Jun Shon, Yooheon Park

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Resin-based dental composites have been developed to restore decayed teeth or modify tooth color due to their excellent physical and chemical properties. Such composites may have intrinsic toxicity due to components released into the mouth during the early stage of polymerization, and afterward as a result of erosion or material decomposition. In addition, resin-based dental composites have potential environmental pollutant by elution of monomers and degradation. Since certain monomers of resin matrices are synthesized from bisphenol A (BPA), which acts as an estrogenic endocrine disruptor, these resin matrices may have estrogenic activity. Therefore, the estrogenic endocrine-disrupting activity of various dental composites should be evaluated. In this study, we evaluated the estrogenic endocrine-disrupting activity of 10 resin composites by using a BRET-based estrogen receptor (ER)α and ERβ dimerization assays and ER transactivation assay. BPA, BisDMA, BisGMA, BisEMA, TEGDMA, HMBP, and DMPA mediated ERα dimerization, and BPA, BisDMA, and DMPA also mediated ERβ dimerization. Except for UDMA and CQ, all the compounds were identified as estrogen agonists or antagonists. In-depth information for the safe use of dental composites was acquired, and it was confirmed how the component of dental composites acts in the ER signaling pathway. Further studies on the low-dose and long-term release of these compounds are needed to ensure the safe use of these resin-based dental composites.

Original languageEnglish
Article number140104
JournalChemosphere
Volume343
DOIs
StatePublished - Dec 2023

Keywords

  • Bioluminescence resonance energy transfer
  • Dimerization assay
  • Estrogen receptor
  • Resin composites
  • Transactivation assay

Fingerprint

Dive into the research topics of 'Comprehensive assessment of the estrogenic activity of resin composites'. Together they form a unique fingerprint.

Cite this