Considerations for crossover design in clinical study

Chi Yeon Lim, Junyong In

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

This article introduces a crossover design that is often used in clinical studies, with the ad-vantage of comparing treatment effects within one study subject. In particular, the advan-tages and disadvantages of the two-period, two-sequence crossover design (2 × 2 or AB/ BA crossover design), which is widely used in clinical practice, are identified, and the ele-ments necessary for analysis are introduced. This article explains the carryover effect, period effect, sequence effect, and period-by-treatment interaction in a crossover design and examines the analysis commands of SAS along with example data. After confirming the carryover effect using a general linear model, the treatment effect is analyzed using a linear mixed effect model.

Original languageEnglish
Pages (from-to)293-299
Number of pages7
JournalKorean Journal of Anesthesiology
Volume74
Issue number4
DOIs
StatePublished - Aug 2021

Keywords

  • Biomedical research
  • Carryover effect
  • Crossover design
  • Linear mixed effect model
  • Statistics
  • Washout period

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