Abstract
This article introduces a crossover design that is often used in clinical studies, with the ad-vantage of comparing treatment effects within one study subject. In particular, the advan-tages and disadvantages of the two-period, two-sequence crossover design (2 × 2 or AB/ BA crossover design), which is widely used in clinical practice, are identified, and the ele-ments necessary for analysis are introduced. This article explains the carryover effect, period effect, sequence effect, and period-by-treatment interaction in a crossover design and examines the analysis commands of SAS along with example data. After confirming the carryover effect using a general linear model, the treatment effect is analyzed using a linear mixed effect model.
Original language | English |
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Pages (from-to) | 293-299 |
Number of pages | 7 |
Journal | Korean Journal of Anesthesiology |
Volume | 74 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2021 |
Keywords
- Biomedical research
- Carryover effect
- Crossover design
- Linear mixed effect model
- Statistics
- Washout period