Construction and analysis of biochemical networks

Michael Binns, Constantinos Theodoropoulos

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Bioprocesses are being implemented for a range of different applications including the production of fuels, chemicals and drugs. Hence, it is becoming increasingly important to understand and model how they function and how they can be modified or designed to give the optimal performance. Here we discuss the construction and analysis of biochemical networks which are the first logical steps towards this goal. The construction of a reaction network is possible through reconstruction: extracting information from literature and from databases. This can be supplemented by reaction prediction methods which can identify steps which are missing from the current knowledge base. Analysis of biochemical systems generally requires some experimental input but can be used to identify important reactions and targets for enhancing the performance of the organism involved. Metabolic flux, pathway and metabolic control analysis can be used to determine the limits, capabilities and potential targets for enhancement respectively.

Original languageEnglish
Title of host publicationNumerical Analysis and Applied Mathematics, ICNAAM 2012 - International Conference of Numerical Analysis and Applied Mathematics
Pages2423-2426
Number of pages4
Edition1
DOIs
StatePublished - 2012
EventInternational Conference of Numerical Analysis and Applied Mathematics, ICNAAM 2012 - Kos, Greece
Duration: 19 Sep 201225 Sep 2012

Publication series

NameAIP Conference Proceedings
Number1
Volume1479
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

ConferenceInternational Conference of Numerical Analysis and Applied Mathematics, ICNAAM 2012
Country/TerritoryGreece
CityKos
Period19/09/1225/09/12

Keywords

  • Flux Blanace Analysis
  • Metabolic Control Analysis
  • Pathway Analysis
  • Reaction Network Construction

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