TY - GEN
T1 - Construction and analysis of biochemical networks
AU - Binns, Michael
AU - Theodoropoulos, Constantinos
PY - 2012
Y1 - 2012
N2 - Bioprocesses are being implemented for a range of different applications including the production of fuels, chemicals and drugs. Hence, it is becoming increasingly important to understand and model how they function and how they can be modified or designed to give the optimal performance. Here we discuss the construction and analysis of biochemical networks which are the first logical steps towards this goal. The construction of a reaction network is possible through reconstruction: extracting information from literature and from databases. This can be supplemented by reaction prediction methods which can identify steps which are missing from the current knowledge base. Analysis of biochemical systems generally requires some experimental input but can be used to identify important reactions and targets for enhancing the performance of the organism involved. Metabolic flux, pathway and metabolic control analysis can be used to determine the limits, capabilities and potential targets for enhancement respectively.
AB - Bioprocesses are being implemented for a range of different applications including the production of fuels, chemicals and drugs. Hence, it is becoming increasingly important to understand and model how they function and how they can be modified or designed to give the optimal performance. Here we discuss the construction and analysis of biochemical networks which are the first logical steps towards this goal. The construction of a reaction network is possible through reconstruction: extracting information from literature and from databases. This can be supplemented by reaction prediction methods which can identify steps which are missing from the current knowledge base. Analysis of biochemical systems generally requires some experimental input but can be used to identify important reactions and targets for enhancing the performance of the organism involved. Metabolic flux, pathway and metabolic control analysis can be used to determine the limits, capabilities and potential targets for enhancement respectively.
KW - Flux Blanace Analysis
KW - Metabolic Control Analysis
KW - Pathway Analysis
KW - Reaction Network Construction
UR - http://www.scopus.com/inward/record.url?scp=84883113331&partnerID=8YFLogxK
U2 - 10.1063/1.4756684
DO - 10.1063/1.4756684
M3 - Conference contribution
AN - SCOPUS:84883113331
SN - 9780735410916
T3 - AIP Conference Proceedings
SP - 2423
EP - 2426
BT - Numerical Analysis and Applied Mathematics, ICNAAM 2012 - International Conference of Numerical Analysis and Applied Mathematics
T2 - International Conference of Numerical Analysis and Applied Mathematics, ICNAAM 2012
Y2 - 19 September 2012 through 25 September 2012
ER -