Abstract
The first and highly stereoselective asymmetric total syntheses of eight-membered ring ether marine natural products (+)-3-(E)-pinnatifidenyne and (+)-3-(Z)-pinnatifidenyne have been accomplished. Notable features of our syntheses include a novel and efficient construction of oxocene 5 by a highly stereo- and regioselective internal alkylation and direct ketone synthesis of ketone 16 from the α-alkyloxy amide moiety in oxocene 5.
Original language | English |
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Pages (from-to) | 10238-10240 |
Number of pages | 3 |
Journal | Journal of the American Chemical Society |
Volume | 125 |
Issue number | 34 |
DOIs | |
State | Published - 27 Aug 2003 |