TY - JOUR
T1 - Cordyceps spp.
T2 - A Review on Its Immune-Stimulatory and Other Biological Potentials
AU - Das, Gitishree
AU - Shin, Han Seung
AU - Leyva-Gómez, Gerardo
AU - Prado-Audelo, María L.Del
AU - Cortes, Hernán
AU - Singh, Yengkhom Disco
AU - Panda, Manasa Kumar
AU - Mishra, Abhay Prakash
AU - Nigam, Manisha
AU - Saklani, Sarla
AU - Chaturi, Praveen Kumar
AU - Martorell, Miquel
AU - Cruz-Martins, Natália
AU - Sharma, Vineet
AU - Garg, Neha
AU - Sharma, Rohit
AU - Patra, Jayanta Kumar
N1 - Publisher Copyright:
© Copyright © 2021 Das, Shin, Leyva-Gómez, Prado-Audelo, Cortes, Singh, Panda, Mishra, Nigam, Saklani, Chaturi, Martorell, Cruz-Martins, Sharma, Garg, Sharma and Patra.
PY - 2021/2/8
Y1 - 2021/2/8
N2 - In recent decades, interest in the Cordyceps genus has amplified due to its immunostimulatory potential. Cordyceps species, its extracts, and bioactive constituents have been related with cytokine production such as interleukin (IL)-1β, IL-2, IL-6, IL-8, IL-10, IL-12, and tumor necrosis factor (TNF)-α, phagocytosis stimulation of immune cells, nitric oxide production by increasing inducible nitric oxide synthase activity, and stimulation of inflammatory response via mitogen-activated protein kinase pathway. Other pharmacological activities like antioxidant, anti-cancer, antihyperlipidemic, anti-diabetic, anti-fatigue, anti-aging, hypocholesterolemic, hypotensive, vasorelaxation, anti-depressant, aphrodisiac, and kidney protection, has been reported in pre-clinical studies. These biological activities are correlated with the bioactive compounds present in Cordyceps including nucleosides, sterols, flavonoids, cyclic peptides, phenolic, bioxanthracenes, polyketides, and alkaloids, being the cyclic peptides compounds the most studied. An organized review of the existing literature was executed by surveying several databanks like PubMed, Scopus, etc. using keywords like Cordyceps, cordycepin, immune system, immunostimulation, immunomodulatory, pharmacology, anti-cancer, anti-viral, clinical trials, ethnomedicine, pharmacology, phytochemical analysis, and different species names. This review collects and analyzes state-of-the-art about the properties of Cordyceps species along with ethnopharmacological properties, application in food, chemical compounds, extraction of bioactive compounds, and various pharmacological properties with a special focus on the stimulatory properties of immunity.
AB - In recent decades, interest in the Cordyceps genus has amplified due to its immunostimulatory potential. Cordyceps species, its extracts, and bioactive constituents have been related with cytokine production such as interleukin (IL)-1β, IL-2, IL-6, IL-8, IL-10, IL-12, and tumor necrosis factor (TNF)-α, phagocytosis stimulation of immune cells, nitric oxide production by increasing inducible nitric oxide synthase activity, and stimulation of inflammatory response via mitogen-activated protein kinase pathway. Other pharmacological activities like antioxidant, anti-cancer, antihyperlipidemic, anti-diabetic, anti-fatigue, anti-aging, hypocholesterolemic, hypotensive, vasorelaxation, anti-depressant, aphrodisiac, and kidney protection, has been reported in pre-clinical studies. These biological activities are correlated with the bioactive compounds present in Cordyceps including nucleosides, sterols, flavonoids, cyclic peptides, phenolic, bioxanthracenes, polyketides, and alkaloids, being the cyclic peptides compounds the most studied. An organized review of the existing literature was executed by surveying several databanks like PubMed, Scopus, etc. using keywords like Cordyceps, cordycepin, immune system, immunostimulation, immunomodulatory, pharmacology, anti-cancer, anti-viral, clinical trials, ethnomedicine, pharmacology, phytochemical analysis, and different species names. This review collects and analyzes state-of-the-art about the properties of Cordyceps species along with ethnopharmacological properties, application in food, chemical compounds, extraction of bioactive compounds, and various pharmacological properties with a special focus on the stimulatory properties of immunity.
KW - clinical studies
KW - cordycepin
KW - cordyceps
KW - ethnopharmacology
KW - immune system
KW - immunomodulatory
KW - immunostimulation
KW - natural medicine
UR - http://www.scopus.com/inward/record.url?scp=85101216825&partnerID=8YFLogxK
U2 - 10.3389/fphar.2020.602364
DO - 10.3389/fphar.2020.602364
M3 - Review article
AN - SCOPUS:85101216825
SN - 1663-9812
VL - 11
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 602364
ER -