Corilagin with inhibitory activity against NO production from Euphorbia supina

Hee Sung Chae, Young Mi Kim, Eun Joo Lee, Hyuk Hwan Song, Sei Ryang Oh, Young Hee Choi, Young Won Chin

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Bioactivity-guided investigation on whole plant of Euphorbia supina, using LPS-induced Raw264.7 cells, led to the identificaiton of a tannin which was not reported from this plant along with four known constituents (quercetin, astragalin, juglanin and methyl gallate). The structure of the tannin was determined as corilagin by the interpretation of NMR (1D and 2D) and MS spectroscopic data. All the isolates were tested for the inhibitory activity against NO production in LPS-induced Raw264.7 cells. Among the tested isolates, corilagin was found to be the most active compound.

Original languageEnglish
Pages (from-to)126-129
Number of pages4
JournalNatural Product Sciences
Volume20
Issue number2
StatePublished - 2014

Keywords

  • Corilagin
  • Euphorbia supina
  • Euphorbiaceae
  • Nitric oxide
  • Tannin

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