Cu(OAc)2-catalyzed tandem Blaise/Pinner-type reaction for one-pot synthesis of pyrimidin-4-ones

Yu Sung Chun; Ju Hyun Kim; Suh Young Choi; Young Ok Ko; Sang Gi Lee

doi:10.1021/ol303153g

Cu(OAc)₂-catalyzed tandem Blaise/Pinner-type reaction for one-pot synthesis of pyrimidin-4-ones

Yu Sung Chun
, Ju Hyun Kim
, Suh Young Choi
, Young Ok Ko
, Sang Gi Lee

Department of Chemistry

Ewha Womans University

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

A novel tandem Blaise/Pinner-type reaction for the one-pot synthesis of pyrimidin-4-ones is described. The Blaise reaction intermediate, formed by addition of a Reformatsky reagent to a nitrile, reacted with a second nitrile chemoselectively in the presence of a catalytic amount of Cu(OAc)₂ to afford pyrimidin-4-ones.

Original language	English
Pages (from-to)	6358-6361
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	24
DOIs	https://doi.org/10.1021/ol303153g
State	Published - 21 Dec 2012

Access to Document

10.1021/ol303153g

Cite this

@article{215dadea34614ddfa75e40756e6d20c4,

title = "Cu(OAc)2-catalyzed tandem Blaise/Pinner-type reaction for one-pot synthesis of pyrimidin-4-ones",

abstract = "A novel tandem Blaise/Pinner-type reaction for the one-pot synthesis of pyrimidin-4-ones is described. The Blaise reaction intermediate, formed by addition of a Reformatsky reagent to a nitrile, reacted with a second nitrile chemoselectively in the presence of a catalytic amount of Cu(OAc)2 to afford pyrimidin-4-ones.",

author = "Chun, \{Yu Sung\} and Kim, \{Ju Hyun\} and Choi, \{Suh Young\} and Ko, \{Young Ok\} and Lee, \{Sang Gi\}",

year = "2012",

month = dec,

day = "21",

doi = "10.1021/ol303153g",

language = "English",

volume = "14",

pages = "6358--6361",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "24",

}

TY - JOUR

T1 - Cu(OAc)2-catalyzed tandem Blaise/Pinner-type reaction for one-pot synthesis of pyrimidin-4-ones

AU - Chun, Yu Sung

AU - Kim, Ju Hyun

AU - Choi, Suh Young

AU - Ko, Young Ok

AU - Lee, Sang Gi

PY - 2012/12/21

Y1 - 2012/12/21

N2 - A novel tandem Blaise/Pinner-type reaction for the one-pot synthesis of pyrimidin-4-ones is described. The Blaise reaction intermediate, formed by addition of a Reformatsky reagent to a nitrile, reacted with a second nitrile chemoselectively in the presence of a catalytic amount of Cu(OAc)2 to afford pyrimidin-4-ones.

AB - A novel tandem Blaise/Pinner-type reaction for the one-pot synthesis of pyrimidin-4-ones is described. The Blaise reaction intermediate, formed by addition of a Reformatsky reagent to a nitrile, reacted with a second nitrile chemoselectively in the presence of a catalytic amount of Cu(OAc)2 to afford pyrimidin-4-ones.

UR - https://www.scopus.com/pages/publications/84871572694

U2 - 10.1021/ol303153g

DO - 10.1021/ol303153g

M3 - Article

AN - SCOPUS:84871572694

SN - 1523-7060

VL - 14

SP - 6358

EP - 6361

JO - Organic Letters

JF - Organic Letters

IS - 24

ER -

Cu(OAc)₂-catalyzed tandem Blaise/Pinner-type reaction for one-pot synthesis of pyrimidin-4-ones

Abstract

Access to Document

Other files and links

Fingerprint

Cite this