TY - JOUR
T1 - Current advances in the detection of neurotransmitters by nanomaterials
T2 - An update
AU - Arumugasamy, Shiva Kumar
AU - Chellasamy, Gayathri
AU - Gopi, Sivalingam
AU - Govindaraju, Saravanan
AU - Yun, Kyusik
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2020/2
Y1 - 2020/2
N2 - Neurotransmitters (NTs) are chemical messengers in the synaptic transmission process. NTs play important roles in human activities, and imbalanced NTs levels in the body lead to severe diseases such as Alzheimer's and Parkinson's diseases. The accurate diagnosis of NTs imbalances has been identified only after patient death through identifying plaques in the brain. Hence, the diagnosis and monitoring of NTs concentrations is important for avoiding serious illnesses. Many researchers have explored the use of robust diagnostic tools with various nanomaterials and techniques. Herein, we investigated the mechanism of reactions between NTs and nanomaterials, the role of nanomaterials in diagnostic tools and the different techniques used in the accurate detection of NTs. Furthermore, we discussed the simultaneous detection of NTs in a single sensing channel, detection in biological samples and future perspectives for nanomaterials in NTs detection.
AB - Neurotransmitters (NTs) are chemical messengers in the synaptic transmission process. NTs play important roles in human activities, and imbalanced NTs levels in the body lead to severe diseases such as Alzheimer's and Parkinson's diseases. The accurate diagnosis of NTs imbalances has been identified only after patient death through identifying plaques in the brain. Hence, the diagnosis and monitoring of NTs concentrations is important for avoiding serious illnesses. Many researchers have explored the use of robust diagnostic tools with various nanomaterials and techniques. Herein, we investigated the mechanism of reactions between NTs and nanomaterials, the role of nanomaterials in diagnostic tools and the different techniques used in the accurate detection of NTs. Furthermore, we discussed the simultaneous detection of NTs in a single sensing channel, detection in biological samples and future perspectives for nanomaterials in NTs detection.
KW - Nanomaterials
KW - Neurotransmitters
KW - Real samples
KW - Sensing techniques
KW - Simultaneous sensor
UR - http://www.scopus.com/inward/record.url?scp=85076590166&partnerID=8YFLogxK
U2 - 10.1016/j.trac.2019.115766
DO - 10.1016/j.trac.2019.115766
M3 - Review article
AN - SCOPUS:85076590166
SN - 0165-9936
VL - 123
JO - TrAC - Trends in Analytical Chemistry
JF - TrAC - Trends in Analytical Chemistry
M1 - 115766
ER -
