Current approaches including novel nano/microtechniques to reduce silicone implant-induced contracture with adverse immune responses

Shin Hyuk Kang, Chanutchamon Sutthiwanjampa, Chan Young Heo, Woo Seob Kim, Soo Hong Lee, Hansoo Park

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

Capsular contracture, which is the pathologic development of fibrous capsules around implants, is a major complication of reconstructive and aesthetic breast surgeries. Capsular contracture can cause implant failure with breast hardening, deformity, and severe pain. The exact mechanisms underlying this complication remain unclear. In addition, anaplastic large cell lymphoma is now widely recognized as a very rare disease associated with breast implants. Foreign body reactions are an inevitable common denominator of capsular contracture. A number of studies have focused on the associated immune responses and their regulation. The present article provides an overview of the currently available techniques, including novel nano/microtechniques, to reduce silicone implant-induced contracture and associated foreign body responses.

Original languageEnglish
Article number1171
JournalInternational Journal of Molecular Sciences
Volume19
Issue number4
DOIs
StatePublished - 12 Apr 2018

Keywords

  • ALCL
  • Capsular contracture
  • Foreign body reaction
  • Nano/microtechniques
  • Silicone breast implant
  • T-cell immunity

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