TY - JOUR
T1 - Current approaches including novel nano/microtechniques to reduce silicone implant-induced contracture with adverse immune responses
AU - Kang, Shin Hyuk
AU - Sutthiwanjampa, Chanutchamon
AU - Heo, Chan Young
AU - Kim, Woo Seob
AU - Lee, Soo Hong
AU - Park, Hansoo
N1 - Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2018/4/12
Y1 - 2018/4/12
N2 - Capsular contracture, which is the pathologic development of fibrous capsules around implants, is a major complication of reconstructive and aesthetic breast surgeries. Capsular contracture can cause implant failure with breast hardening, deformity, and severe pain. The exact mechanisms underlying this complication remain unclear. In addition, anaplastic large cell lymphoma is now widely recognized as a very rare disease associated with breast implants. Foreign body reactions are an inevitable common denominator of capsular contracture. A number of studies have focused on the associated immune responses and their regulation. The present article provides an overview of the currently available techniques, including novel nano/microtechniques, to reduce silicone implant-induced contracture and associated foreign body responses.
AB - Capsular contracture, which is the pathologic development of fibrous capsules around implants, is a major complication of reconstructive and aesthetic breast surgeries. Capsular contracture can cause implant failure with breast hardening, deformity, and severe pain. The exact mechanisms underlying this complication remain unclear. In addition, anaplastic large cell lymphoma is now widely recognized as a very rare disease associated with breast implants. Foreign body reactions are an inevitable common denominator of capsular contracture. A number of studies have focused on the associated immune responses and their regulation. The present article provides an overview of the currently available techniques, including novel nano/microtechniques, to reduce silicone implant-induced contracture and associated foreign body responses.
KW - ALCL
KW - Capsular contracture
KW - Foreign body reaction
KW - Nano/microtechniques
KW - Silicone breast implant
KW - T-cell immunity
UR - http://www.scopus.com/inward/record.url?scp=85045415021&partnerID=8YFLogxK
U2 - 10.3390/ijms19041171
DO - 10.3390/ijms19041171
M3 - Review article
C2 - 29649133
AN - SCOPUS:85045415021
SN - 1661-6596
VL - 19
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 4
M1 - 1171
ER -