Current clinical application of dantrolene sodium

Hong Seuk Yang, Jae Moon Choi, Junyong In, Tae Yun Sung, Yong Beom Kim, Shofina Sultana

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Dantrolene sodium (DS) was first introduced as an oral antispasmodic drug. However, in 1975, DS was demonstrated to be effective for managing malignant hyperthermia (MH) and was adopted as the primary therapeutic drug after intravenous administration. However, it is difficult to administer DS intravenously to manage MH. MH is life-threatening, pharmacog-enomically related, and induced by depolarizing neuromuscular blocking agents or inhalational anesthetics. All anesthesiologists should know the pharmacology of DS. DS suppresses Ca2+ release from ryanodine receptors (RyRs). RyRs are expressed in various tissues, although their distribution differs among subtypes. The anatomical and physiological functions of RyRs have also been demonstrated as effective therapeutic drugs for cardiac arrhythmias, Alzheimer’s disease, and other RyR-related diseases. Recently, a new formulation was introduced that enhanced the hydrophilicity of the lipophilic DS. The authors summarize the pharmacological properties of DS and comment on its indications, contraindications, adverse effects, and interactions with other drugs by reviewing reference articles.

Original languageEnglish
Pages (from-to)220-232
Number of pages13
JournalAnesthesia and Pain Medicine
Volume18
Issue number3
DOIs
StatePublished - Jul 2023

Keywords

  • Adverse events
  • Dantrolene
  • Malignant hyperthermia
  • Pharmacology
  • Ryanodine receptor calcium release channel

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