Current investigations into the genotoxicity of zinc oxide and silica nanoparticles in mammalian models in vitro and in vivo: Carcinogenic/genotoxic potential, relevant mechanisms and biomarkers, artifacts, and limitations

Jee Young Kwon, Preeyaporn Koedrith, Young Rok Seo

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations

Abstract

Engineered nanoparticles (NPs) are widely used in many sectors, such as food, medicine, military, and sport, but their unique characteristics may cause deleterious health effects. Close attention is being paid to metal NP genotoxicity; however, NP genotoxic/carcinogenic effects and the underlying mechanisms remain to be elucidated. In this review, we address some metal and metal oxide NPs of interest and current genotoxicity tests in vitro and in vivo. Metal NPs can cause DNA damage such as chromosomal aberrations, DNA strand breaks, oxidative DNA damage, and mutations. We also discuss several parameters that may affect genotoxic response, including physicochemical properties, widely used assays/end point tests, and experimental conditions. Although potential biomarkers of nanogenotoxicity or carcinogenicity are suggested, inconsistent findings in the literature render results inconclusive due to a variety of factors. Advantages and limitations related to different methods for investigating genotoxicity are described, and future directions and recommendations for better understanding genotoxic potential are addressed.

Original languageEnglish
Pages (from-to)271-286
Number of pages16
JournalInternational Journal of Nanomedicine
Volume9
DOIs
StatePublished - 15 Dec 2014

Keywords

  • Carcinogenicity
  • Exposure assessment
  • Genotoxicity
  • Nanoparticles
  • Risk evaluation

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