Cu(triNHC)-catalyzed polymerization of glycidol to produce ultralow-branched polyglycerol

Kihyuk Sung, Jinsu Baek, Soonyoung Choi, Byeong Su Kim, Sang Ho Lee, In Hwan Lee, Hye Young Jang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

We have successfully synthesized a novel form of polyglycerol with an unprecedentedly low degree of branching (DB = 0.08-0.18), eliminating the need for glycidol protection. Leveraging the remarkable efficiency and selectivity of our Cu(triNHC) catalyst, comprising copper(i) ions and NHC ligands, we achieved a highly selective polymerization process. The proposed Cu-coordination mechanisms presented the formation of linear L1,3 units while effectively suppressing dendritic units. Consequently, our pioneering approach yielded polyglycerol with an ultralow DB and exceptional yields. To comprehensively assess the physical properties and topology of the synthesized polyglycerol, we employed 1H diffusion-ordered spectroscopy, size-exclusion chromatography, and matrix-assisted laser desorption/ionization-time of flight spectrometry. Remarkably, the ultralow-branched cyclic polyglycerol (DB = 0.08) synthesized at 0 °C showcased extraordinary characteristics, exhibiting the lowest diffusion coefficient and the highest molecular weight. This achievement establishes the significant potential of our polyglycerol with a low degree of branching, revolutionizing the field of biocompatible polymers.

Original languageEnglish
Pages (from-to)24071-24076
Number of pages6
JournalRSC Advances
Volume13
Issue number34
DOIs
StatePublished - 11 Aug 2023

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