Cyclopeptides from the Sponge Stylissa flabelliformis

Oh Seok Kwon; Chang Kwon Kim; Woong Sub Byun; Joonseok Oh; Yeon Ju Lee; Hyi Seung Lee; Chung J. Sim; Dong Chan Oh; Sang Kook Lee; Ki Bong Oh; Jongheon Shin

doi:10.1021/acs.jnatprod.8b00121

Cyclopeptides from the Sponge Stylissa flabelliformis

Oh Seok Kwon
, Chang Kwon Kim
, Woong Sub Byun
, Joonseok Oh
, Yeon Ju Lee
, Hyi Seung Lee
, Chung J. Sim
, Dong Chan Oh
, Sang Kook Lee
, Ki Bong Oh
, Jongheon Shin

Department of Pharmacy

Seoul National University
Yale University
Korea Institute of Ocean Science & Technology
Hannam University

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Three new cyclopeptides, phakellistatins 20-22 (1-3), as well as 10 known cyclopeptides of the same structural class were isolated from the tropical sponge Stylissa flabelliformis. By a combination of chemical and spectroscopic methods, the structures of the new compounds were determined to be an epimeric mixture of cycloheptapeptides (1) and two epimeric cyclodecapeptides (2 and 3) related to the phakellistatins. The cyclopeptides were evaluated for in vitro cytotoxicity against a variety of cancer cell lines, and compounds 2 and 3 exhibited significant activity.

Original language	English
Pages (from-to)	1426-1434
Number of pages	9
Journal	Journal of Natural Products
Volume	81
Issue number	6
DOIs	https://doi.org/10.1021/acs.jnatprod.8b00121
State	Published - 22 Jun 2018

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SDG 3 Good Health and Well-being

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10.1021/acs.jnatprod.8b00121

Cite this

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title = "Cyclopeptides from the Sponge Stylissa flabelliformis",

abstract = "Three new cyclopeptides, phakellistatins 20-22 (1-3), as well as 10 known cyclopeptides of the same structural class were isolated from the tropical sponge Stylissa flabelliformis. By a combination of chemical and spectroscopic methods, the structures of the new compounds were determined to be an epimeric mixture of cycloheptapeptides (1) and two epimeric cyclodecapeptides (2 and 3) related to the phakellistatins. The cyclopeptides were evaluated for in vitro cytotoxicity against a variety of cancer cell lines, and compounds 2 and 3 exhibited significant activity.",

author = "Kwon, \{Oh Seok\} and Kim, \{Chang Kwon\} and Byun, \{Woong Sub\} and Joonseok Oh and Lee, \{Yeon Ju\} and Lee, \{Hyi Seung\} and Sim, \{Chung J.\} and Oh, \{Dong Chan\} and Lee, \{Sang Kook\} and Oh, \{Ki Bong\} and Jongheon Shin",

note = "Publisher Copyright: {\textcopyright} 2018 American Chemical Society and American Society of Pharmacognosy.",

year = "2018",

month = jun,

day = "22",

doi = "10.1021/acs.jnatprod.8b00121",

language = "English",

volume = "81",

pages = "1426--1434",

journal = "Journal of Natural Products",

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TY - JOUR

T1 - Cyclopeptides from the Sponge Stylissa flabelliformis

AU - Kwon, Oh Seok

AU - Kim, Chang Kwon

AU - Byun, Woong Sub

AU - Oh, Joonseok

AU - Lee, Yeon Ju

AU - Lee, Hyi Seung

AU - Sim, Chung J.

AU - Oh, Dong Chan

AU - Lee, Sang Kook

AU - Oh, Ki Bong

AU - Shin, Jongheon

PY - 2018/6/22

Y1 - 2018/6/22

N2 - Three new cyclopeptides, phakellistatins 20-22 (1-3), as well as 10 known cyclopeptides of the same structural class were isolated from the tropical sponge Stylissa flabelliformis. By a combination of chemical and spectroscopic methods, the structures of the new compounds were determined to be an epimeric mixture of cycloheptapeptides (1) and two epimeric cyclodecapeptides (2 and 3) related to the phakellistatins. The cyclopeptides were evaluated for in vitro cytotoxicity against a variety of cancer cell lines, and compounds 2 and 3 exhibited significant activity.

AB - Three new cyclopeptides, phakellistatins 20-22 (1-3), as well as 10 known cyclopeptides of the same structural class were isolated from the tropical sponge Stylissa flabelliformis. By a combination of chemical and spectroscopic methods, the structures of the new compounds were determined to be an epimeric mixture of cycloheptapeptides (1) and two epimeric cyclodecapeptides (2 and 3) related to the phakellistatins. The cyclopeptides were evaluated for in vitro cytotoxicity against a variety of cancer cell lines, and compounds 2 and 3 exhibited significant activity.

UR - https://www.scopus.com/pages/publications/85049037621

U2 - 10.1021/acs.jnatprod.8b00121

DO - 10.1021/acs.jnatprod.8b00121

M3 - Article

C2 - 29893558

AN - SCOPUS:85049037621

SN - 0163-3864

VL - 81

SP - 1426

EP - 1434

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 6

ER -

Cyclopeptides from the Sponge Stylissa flabelliformis

Abstract

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