TY - JOUR
T1 - Demographics Prediction and Heatmap Generation From OCT Images of Anterior Segment of the Eye
T2 - A Vision Transformer Model Study
AU - Lee, Yun Jeong
AU - Choe, Sooyeon
AU - Wy, Seoyoung
AU - Jang, Mirinae
AU - Jeoung, Jin Wook
AU - Choi, Hyuk Jin
AU - Park, Ki Ho
AU - Sun, Sukkyu
AU - Kim, Young Kook
N1 - Publisher Copyright:
© 2022 The Authors.
PY - 2022/11
Y1 - 2022/11
N2 - Purpose: To predict demographic characteristics from anterior segment optical coherence tomography (AS-OCT) images of eyes using a Vision Transformer (ViT) model. Methods: A total of 2970 AS-OCT images were used to train, validate, and test a ViT to predict age and sex, and 2616 images were used for height, weight, and body mass index (BMI). The main outcome measure was the area under the receiver operating characteristic curve (AUC) of the ViT. Results: The ViT achieved the largest AUC (0.910) for differentiating age ≤75 versus >75 years, followed by age ≤60 versus 60–75 versus >75 years (AUC, 0.844), and for discriminating sex (AUC, 0.665). The prediction abilities for the other demographic characteristics were lower: an AUC of 0.521 for classifying height ≤170 versus >170 cm in males and ≤155 versus >155 cm in females; 0.522 for weight <70 versus ≥70 kg in males and 0.503 for <55 versus ≥55 kg in females, and 0.517 for BMI <23 versus 23–25 versus ≥25 kg/m2. Heatmaps highlighted the area of the iridocorneal angle for its contribution to the prediction of age ≤75 versus >75 years. Conclusions: Although the ViT demonstrated a good ability to classify age from AS-OCT images, it performed poorly for sex, height, weight, and BMI. The heatmap obtained of the prediction will provide clues to understanding the age-related anterior segment changes in eyes. Translational Relevance: The ViT can determine age-related anterior segment structural changes using AS-OCT images, which will aid clinicians in the management of ocular diseases.
AB - Purpose: To predict demographic characteristics from anterior segment optical coherence tomography (AS-OCT) images of eyes using a Vision Transformer (ViT) model. Methods: A total of 2970 AS-OCT images were used to train, validate, and test a ViT to predict age and sex, and 2616 images were used for height, weight, and body mass index (BMI). The main outcome measure was the area under the receiver operating characteristic curve (AUC) of the ViT. Results: The ViT achieved the largest AUC (0.910) for differentiating age ≤75 versus >75 years, followed by age ≤60 versus 60–75 versus >75 years (AUC, 0.844), and for discriminating sex (AUC, 0.665). The prediction abilities for the other demographic characteristics were lower: an AUC of 0.521 for classifying height ≤170 versus >170 cm in males and ≤155 versus >155 cm in females; 0.522 for weight <70 versus ≥70 kg in males and 0.503 for <55 versus ≥55 kg in females, and 0.517 for BMI <23 versus 23–25 versus ≥25 kg/m2. Heatmaps highlighted the area of the iridocorneal angle for its contribution to the prediction of age ≤75 versus >75 years. Conclusions: Although the ViT demonstrated a good ability to classify age from AS-OCT images, it performed poorly for sex, height, weight, and BMI. The heatmap obtained of the prediction will provide clues to understanding the age-related anterior segment changes in eyes. Translational Relevance: The ViT can determine age-related anterior segment structural changes using AS-OCT images, which will aid clinicians in the management of ocular diseases.
KW - anterior segment optical coherence tomography
KW - deep learning
KW - demographic characteristics
KW - prediction
KW - vision transformer model
UR - http://www.scopus.com/inward/record.url?scp=85141714715&partnerID=8YFLogxK
U2 - 10.1167/tvst.11.11.7
DO - 10.1167/tvst.11.11.7
M3 - Article
C2 - 36355387
AN - SCOPUS:85141714715
SN - 2164-2591
VL - 11
JO - Translational Vision Science and Technology
JF - Translational Vision Science and Technology
IS - 11
M1 - 7
ER -