Deoxyribozyme-loaded nano-graphene oxide for simultaneous sensing and silencing of the hepatitis C virus gene in liver cells

Seongchan Kim, Soo Ryoon Ryoo, Hee Kyung Na, Young Kwan Kim, Byong Seok Choi, Younghoon Lee, Dong Eun Kim, Dal Hee Min

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

The multifunctional DNAzyme (Dz) delivery system is developed based on nano-sized graphene oxide (nGO) for simultaneous detection and knockdown of the target gene. The Dz/nGO complex system allowed convenient monitoring of HCV mRNA in living cells and silencing of the HCV gene expression by Dz-mediated catalytic cleavage concurrently.

Original languageEnglish
Pages (from-to)8241-8243
Number of pages3
JournalChemical Communications
Volume49
Issue number74
DOIs
StatePublished - 20 Aug 2013

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