Deoxyribozyme-loaded nano-graphene oxide for simultaneous sensing and silencing of the hepatitis C virus gene in liver cells

Seongchan Kim; Soo Ryoon Ryoo; Hee Kyung Na; Young Kwan Kim; Byong Seok Choi; Younghoon Lee; Dong Eun Kim; Dal Hee Min

doi:10.1039/c3cc43368d

Deoxyribozyme-loaded nano-graphene oxide for simultaneous sensing and silencing of the hepatitis C virus gene in liver cells

Seongchan Kim
, Soo Ryoon Ryoo
, Hee Kyung Na
, Young Kwan Kim
, Byong Seok Choi
, Younghoon Lee
, Dong Eun Kim
, Dal Hee Min

Department of Chemistry

Seoul National University
Korea Advanced Institute of Science and Technology
Konkuk University

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

The multifunctional DNAzyme (Dz) delivery system is developed based on nano-sized graphene oxide (nGO) for simultaneous detection and knockdown of the target gene. The Dz/nGO complex system allowed convenient monitoring of HCV mRNA in living cells and silencing of the HCV gene expression by Dz-mediated catalytic cleavage concurrently.

Original language	English
Pages (from-to)	8241-8243
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	74
DOIs	https://doi.org/10.1039/c3cc43368d
State	Published - 20 Aug 2013

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10.1039/c3cc43368d

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title = "Deoxyribozyme-loaded nano-graphene oxide for simultaneous sensing and silencing of the hepatitis C virus gene in liver cells",

abstract = "The multifunctional DNAzyme (Dz) delivery system is developed based on nano-sized graphene oxide (nGO) for simultaneous detection and knockdown of the target gene. The Dz/nGO complex system allowed convenient monitoring of HCV mRNA in living cells and silencing of the HCV gene expression by Dz-mediated catalytic cleavage concurrently.",

author = "Seongchan Kim and Ryoo, \{Soo Ryoon\} and Na, \{Hee Kyung\} and Kim, \{Young Kwan\} and Choi, \{Byong Seok\} and Younghoon Lee and Kim, \{Dong Eun\} and Min, \{Dal Hee\}",

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doi = "10.1039/c3cc43368d",

language = "English",

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T1 - Deoxyribozyme-loaded nano-graphene oxide for simultaneous sensing and silencing of the hepatitis C virus gene in liver cells

AU - Kim, Seongchan

AU - Ryoo, Soo Ryoon

AU - Na, Hee Kyung

AU - Kim, Young Kwan

AU - Choi, Byong Seok

AU - Lee, Younghoon

AU - Kim, Dong Eun

AU - Min, Dal Hee

PY - 2013/8/20

Y1 - 2013/8/20

N2 - The multifunctional DNAzyme (Dz) delivery system is developed based on nano-sized graphene oxide (nGO) for simultaneous detection and knockdown of the target gene. The Dz/nGO complex system allowed convenient monitoring of HCV mRNA in living cells and silencing of the HCV gene expression by Dz-mediated catalytic cleavage concurrently.

AB - The multifunctional DNAzyme (Dz) delivery system is developed based on nano-sized graphene oxide (nGO) for simultaneous detection and knockdown of the target gene. The Dz/nGO complex system allowed convenient monitoring of HCV mRNA in living cells and silencing of the HCV gene expression by Dz-mediated catalytic cleavage concurrently.

UR - https://www.scopus.com/pages/publications/84882617707

U2 - 10.1039/c3cc43368d

DO - 10.1039/c3cc43368d

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AN - SCOPUS:84882617707

SN - 1359-7345

VL - 49

SP - 8241

EP - 8243

JO - Chemical Communications

JF - Chemical Communications

IS - 74

ER -

Deoxyribozyme-loaded nano-graphene oxide for simultaneous sensing and silencing of the hepatitis C virus gene in liver cells

Abstract

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