Design, synthesis, and anticancer activity of fluorocyclopentenyl-pyrimidines.

Long Xuan Zhao, Mikyung Yun, Hea Ok Kim, Jeong A. Lee, Won Jun Choi, Kang Man Lee, Sang Kook Lee, Young B. Lee, Chang Ho Ahn, Lak Shin Jeong

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Novel pyrimidine nucleosides with fluorocyclopentene ring were synthesized from D-ribose via stereoselective Grignard reaction and electrophilic vinyl fluorination as key steps. Among compounds tested, cytosine derivative 15a was found to show high growth inhibition against a broad range of human tumor cell lines.

Original languageEnglish
Pages (from-to)107-108
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number49
DOIs
StatePublished - 2005

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