Abstract
Novel pyrimidine nucleosides with fluorocyclopentene ring were synthesized from D-ribose via stereoselective Grignard reaction and electrophilic vinyl fluorination as key steps. Among compounds tested, cytosine derivative 15a was found to show high growth inhibition against a broad range of human tumor cell lines.
Original language | English |
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Pages (from-to) | 107-108 |
Number of pages | 2 |
Journal | Nucleic acids symposium series (2004) |
Issue number | 49 |
DOIs | |
State | Published - 2005 |