Design, synthesis, and anticancer activity of fluorocyclopentenyl-pyrimidines.

Long Xuan Zhao; Mikyung Yun; Hea Ok Kim; Jeong A. Lee; Won Jun Choi; Kang Man Lee; Sang Kook Lee; Young B. Lee; Chang Ho Ahn; Lak Shin Jeong

doi:10.1093/nass/49.1.107

Design, synthesis, and anticancer activity of fluorocyclopentenyl-pyrimidines.

Long Xuan Zhao
, Mikyung Yun
, Hea Ok Kim
, Jeong A. Lee
, Won Jun Choi
, Kang Man Lee
, Sang Kook Lee
, Young B. Lee
, Chang Ho Ahn
, Lak Shin Jeong

Department of Pharmacy

Ewha Womans University

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Novel pyrimidine nucleosides with fluorocyclopentene ring were synthesized from D-ribose via stereoselective Grignard reaction and electrophilic vinyl fluorination as key steps. Among compounds tested, cytosine derivative 15a was found to show high growth inhibition against a broad range of human tumor cell lines.

Original language	English
Pages (from-to)	107-108
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	49
DOIs	https://doi.org/10.1093/nass/49.1.107
State	Published - 2005

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10.1093/nass/49.1.107

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title = "Design, synthesis, and anticancer activity of fluorocyclopentenyl-pyrimidines.",

abstract = "Novel pyrimidine nucleosides with fluorocyclopentene ring were synthesized from D-ribose via stereoselective Grignard reaction and electrophilic vinyl fluorination as key steps. Among compounds tested, cytosine derivative 15a was found to show high growth inhibition against a broad range of human tumor cell lines.",

author = "Zhao, \{Long Xuan\} and Mikyung Yun and Kim, \{Hea Ok\} and Lee, \{Jeong A.\} and Choi, \{Won Jun\} and Lee, \{Kang Man\} and Lee, \{Sang Kook\} and Lee, \{Young B.\} and Ahn, \{Chang Ho\} and Jeong, \{Lak Shin\}",

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doi = "10.1093/nass/49.1.107",

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T1 - Design, synthesis, and anticancer activity of fluorocyclopentenyl-pyrimidines.

AU - Zhao, Long Xuan

AU - Yun, Mikyung

AU - Kim, Hea Ok

AU - Lee, Jeong A.

AU - Choi, Won Jun

AU - Lee, Kang Man

AU - Lee, Sang Kook

AU - Lee, Young B.

AU - Ahn, Chang Ho

AU - Jeong, Lak Shin

PY - 2005

Y1 - 2005

N2 - Novel pyrimidine nucleosides with fluorocyclopentene ring were synthesized from D-ribose via stereoselective Grignard reaction and electrophilic vinyl fluorination as key steps. Among compounds tested, cytosine derivative 15a was found to show high growth inhibition against a broad range of human tumor cell lines.

AB - Novel pyrimidine nucleosides with fluorocyclopentene ring were synthesized from D-ribose via stereoselective Grignard reaction and electrophilic vinyl fluorination as key steps. Among compounds tested, cytosine derivative 15a was found to show high growth inhibition against a broad range of human tumor cell lines.

UR - https://www.scopus.com/pages/publications/39049178835

U2 - 10.1093/nass/49.1.107

DO - 10.1093/nass/49.1.107

M3 - Article

C2 - 17150656

AN - SCOPUS:39049178835

SN - 1746-8272

SP - 107

EP - 108

JO - Nucleic acids symposium series (2004)

JF - Nucleic acids symposium series (2004)

IS - 49

ER -

Design, synthesis, and anticancer activity of fluorocyclopentenyl-pyrimidines.

Abstract

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