Detailed investigations of rare earth (Yb, Er and Pr) based inorganic metal-ion complexes for antibacterial and anticancer applications

Kavitha Andiappan; Anandhavelu Sanmugam; Easwaramoorthy Deivanayagam; K. Karuppasamy; Hyun Seok Kim; Dhanasekaran Vikraman

doi:10.1016/j.inoche.2023.110510

Detailed investigations of rare earth (Yb, Er and Pr) based inorganic metal-ion complexes for antibacterial and anticancer applications

Kavitha Andiappan
, Anandhavelu Sanmugam
, Easwaramoorthy Deivanayagam
, K. Karuppasamy
, Hyun Seok Kim
, Dhanasekaran Vikraman

Chennai Institute of Technology
B.S. Abdur Rahman Crescent Institute of Science and Technology
Sri Venkateswara College of Engineering, Sriperumbudur
Dongguk University

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A condensation chemical reaction was employed to from the Schiff base ligand and its lanthanide doped metal complexes. The synthesized ligand and metal complexes were extensively used as antibacterial agents versus Pseudomonas aeruginosa and Staphylococcus aureus pathogens. Schiff-praseodymium (Schiff-Pr) complex showed the improved antibacterial properties against the both pathogens among the other synthesized complexes. The synthesized Schiff-Pr metal complexes produced the significant anticancer activity against the cervical and human breast cancer cell lines. Chemically stained Schiff-Pr metal complex surfaces treated against cancer cells exhibited strong metal ion affinity with cell walls, leading to deoxyribonucleic acid fragmentation and arresting cell propagation.

Original language	English
Article number	110510
Journal	Inorganic Chemistry Communications
Volume	150
DOIs	https://doi.org/10.1016/j.inoche.2023.110510
State	Published - Apr 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antibacterial
Anticancer
HeLa
MCF7
Rare earth metal
Schiff base

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10.1016/j.inoche.2023.110510

Cite this

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title = "Detailed investigations of rare earth (Yb, Er and Pr) based inorganic metal-ion complexes for antibacterial and anticancer applications",

abstract = "A condensation chemical reaction was employed to from the Schiff base ligand and its lanthanide doped metal complexes. The synthesized ligand and metal complexes were extensively used as antibacterial agents versus Pseudomonas aeruginosa and Staphylococcus aureus pathogens. Schiff-praseodymium (Schiff-Pr) complex showed the improved antibacterial properties against the both pathogens among the other synthesized complexes. The synthesized Schiff-Pr metal complexes produced the significant anticancer activity against the cervical and human breast cancer cell lines. Chemically stained Schiff-Pr metal complex surfaces treated against cancer cells exhibited strong metal ion affinity with cell walls, leading to deoxyribonucleic acid fragmentation and arresting cell propagation.",

keywords = "Antibacterial, Anticancer, HeLa, MCF7, Rare earth metal, Schiff base",

author = "Kavitha Andiappan and Anandhavelu Sanmugam and Easwaramoorthy Deivanayagam and K. Karuppasamy and Kim, \{Hyun Seok\} and Dhanasekaran Vikraman",

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year = "2023",

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doi = "10.1016/j.inoche.2023.110510",

language = "English",

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TY - JOUR

T1 - Detailed investigations of rare earth (Yb, Er and Pr) based inorganic metal-ion complexes for antibacterial and anticancer applications

AU - Andiappan, Kavitha

AU - Sanmugam, Anandhavelu

AU - Deivanayagam, Easwaramoorthy

AU - Karuppasamy, K.

AU - Kim, Hyun Seok

AU - Vikraman, Dhanasekaran

PY - 2023/4

Y1 - 2023/4

N2 - A condensation chemical reaction was employed to from the Schiff base ligand and its lanthanide doped metal complexes. The synthesized ligand and metal complexes were extensively used as antibacterial agents versus Pseudomonas aeruginosa and Staphylococcus aureus pathogens. Schiff-praseodymium (Schiff-Pr) complex showed the improved antibacterial properties against the both pathogens among the other synthesized complexes. The synthesized Schiff-Pr metal complexes produced the significant anticancer activity against the cervical and human breast cancer cell lines. Chemically stained Schiff-Pr metal complex surfaces treated against cancer cells exhibited strong metal ion affinity with cell walls, leading to deoxyribonucleic acid fragmentation and arresting cell propagation.

AB - A condensation chemical reaction was employed to from the Schiff base ligand and its lanthanide doped metal complexes. The synthesized ligand and metal complexes were extensively used as antibacterial agents versus Pseudomonas aeruginosa and Staphylococcus aureus pathogens. Schiff-praseodymium (Schiff-Pr) complex showed the improved antibacterial properties against the both pathogens among the other synthesized complexes. The synthesized Schiff-Pr metal complexes produced the significant anticancer activity against the cervical and human breast cancer cell lines. Chemically stained Schiff-Pr metal complex surfaces treated against cancer cells exhibited strong metal ion affinity with cell walls, leading to deoxyribonucleic acid fragmentation and arresting cell propagation.

KW - Antibacterial

KW - Anticancer

KW - HeLa

KW - MCF7

KW - Rare earth metal

KW - Schiff base

UR - https://www.scopus.com/pages/publications/85148043147

U2 - 10.1016/j.inoche.2023.110510

DO - 10.1016/j.inoche.2023.110510

M3 - Article

AN - SCOPUS:85148043147

SN - 1387-7003

VL - 150

JO - Inorganic Chemistry Communications

JF - Inorganic Chemistry Communications

M1 - 110510

ER -

Detailed investigations of rare earth (Yb, Er and Pr) based inorganic metal-ion complexes for antibacterial and anticancer applications

Abstract

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Keywords

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