@inproceedings{081a469ad4b14687bba209ec5fc79f0b,
title = "Detecting remote homolog by protein similarity network",
abstract = "Homolog search is the central approach to find out the characteristics of given sequence since homologs share the similar biological role. However it is not easy to detect remote homolog because they do not show distinct sequence identity. We constructed the protein similarity network weighted by sequence and structural similarity, and utilized it to identify homologs. When comparing the ROC50 curve, our method detected twice more homologs at the SCOP superfamily level than PSI-BLAST. Our study demonstrates that exploiting protein structure similarity network improves remote homolog search by reflecting global information in protein space which cannot be detected by conventional localized search methods.",
keywords = "Protein similarity network, Remote homolog detection",
author = "Jeong, {Chan Seok} and Minho Lee and Dongsup Kim",
note = "Publisher Copyright: {\textcopyright} International Federation for Medical and Biological Engineering 2007.; 10th World Congress on Medical Physics and Biomedical Engineering, WC 2006 ; Conference date: 27-08-2006 Through 01-09-2006",
year = "2007",
doi = "10.1007/978-3-540-36841-0_51",
language = "English",
isbn = "9783540368397",
series = "IFMBE Proceedings",
publisher = "Springer Verlag",
number = "1",
pages = "171--173",
editor = "Kim, {Sun I.} and Suh, {Tae Suk}",
booktitle = "IFMBE Proceedings",
address = "Germany",
edition = "1",
}