Development of a docetaxel micellar formulation using poly(Ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG) with successful reconstitution for tumor targeted drug delivery

Taehoon Sim; Jae Eun Kim; Ngoc Ha Hoang; Jin Kook Kang; Chaemin Lim; Dong Shik Kim; Eun Seong Lee; Yu Seok Youn; Han Gon Choi; Hyo Kyung Han; Kwon Yeon Weon; Kyung Taek Oh

doi:10.1080/10717544.2018.1477865

Development of a docetaxel micellar formulation using poly(Ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG) with successful reconstitution for tumor targeted drug delivery

Taehoon Sim, Jae Eun Kim, Ngoc Ha Hoang, Jin Kook Kang, Chaemin Lim, Dong Shik Kim, Eun Seong Lee, Yu Seok Youn, Han Gon Choi, Hyo Kyung Han, Kwon Yeon Weon, Kyung Taek Oh

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Docetaxel (DTX)-loaded polymeric micelles (DTBM) were formulated using the triblock copolymer, poly(ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG), to comprehensively study their pharmaceutical application as anticancer nanomedicine. DTBM showed a stable formulation of anticancer nanomedicine that could be reconstituted after lyophilization (DTBM-R) in the presence of PEG 2000 and D-mannitol (Man) as surfactant and protectant, respectively. DTBM-R showed a particle size less than 150nm and greater than 90% of DTX recovery after reconstitution. The robustly formed micelles might minimize systemic toxicity due to their sustained drug release and also maximize antitumor efficacy through increased accumulation and release of DTX from the micelles. From the pharmaceutical development point of view, DTBM-R showing successful reconstitution could be considered as a potent nanomedicine for tumor treatment.

Original language	English
Pages (from-to)	1371-1380
Number of pages	10
Journal	Drug Delivery
Volume	25
Issue number	1
DOIs	https://doi.org/10.1080/10717544.2018.1477865
State	Published - 2018

Keywords

Cancer
Lyophilization
Nanomedicine
Polymeric micelle
Reconstitution

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/10717544.2018.1477865

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Sim, T., Kim, J. E., Hoang, N. H., Kang, J. K., Lim, C., Kim, D. S., Lee, E. S., Youn, Y. S., Choi, H. G., Han, H. K., Weon, K. Y., & Oh, K. T. (2018). Development of a docetaxel micellar formulation using poly(Ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG) with successful reconstitution for tumor targeted drug delivery. Drug Delivery, 25(1), 1371-1380. https://doi.org/10.1080/10717544.2018.1477865

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title = "Development of a docetaxel micellar formulation using poly(Ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG) with successful reconstitution for tumor targeted drug delivery",

abstract = "Docetaxel (DTX)-loaded polymeric micelles (DTBM) were formulated using the triblock copolymer, poly(ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG), to comprehensively study their pharmaceutical application as anticancer nanomedicine. DTBM showed a stable formulation of anticancer nanomedicine that could be reconstituted after lyophilization (DTBM-R) in the presence of PEG 2000 and D-mannitol (Man) as surfactant and protectant, respectively. DTBM-R showed a particle size less than 150nm and greater than 90% of DTX recovery after reconstitution. The robustly formed micelles might minimize systemic toxicity due to their sustained drug release and also maximize antitumor efficacy through increased accumulation and release of DTX from the micelles. From the pharmaceutical development point of view, DTBM-R showing successful reconstitution could be considered as a potent nanomedicine for tumor treatment.",

keywords = "Cancer, Lyophilization, Nanomedicine, Polymeric micelle, Reconstitution",

author = "Taehoon Sim and Kim, {Jae Eun} and Hoang, {Ngoc Ha} and Kang, {Jin Kook} and Chaemin Lim and Kim, {Dong Shik} and Lee, {Eun Seong} and Youn, {Yu Seok} and Choi, {Han Gon} and Han, {Hyo Kyung} and Weon, {Kwon Yeon} and Oh, {Kyung Taek}",

note = "Publisher Copyright: {\textcopyright} 2018 The Author(s).",

year = "2018",

doi = "10.1080/10717544.2018.1477865",

language = "English",

volume = "25",

pages = "1371--1380",

journal = "Drug Delivery",

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}

Sim, T, Kim, JE, Hoang, NH, Kang, JK, Lim, C, Kim, DS, Lee, ES, Youn, YS, Choi, HG, Han, HK, Weon, KY & Oh, KT 2018, 'Development of a docetaxel micellar formulation using poly(Ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG) with successful reconstitution for tumor targeted drug delivery', Drug Delivery, vol. 25, no. 1, pp. 1371-1380. https://doi.org/10.1080/10717544.2018.1477865

Development of a docetaxel micellar formulation using poly(Ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG) with successful reconstitution for tumor targeted drug delivery. / Sim, Taehoon; Kim, Jae Eun; Hoang, Ngoc Ha et al.
In: Drug Delivery, Vol. 25, No. 1, 2018, p. 1371-1380.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Development of a docetaxel micellar formulation using poly(Ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG) with successful reconstitution for tumor targeted drug delivery

AU - Sim, Taehoon

AU - Kim, Jae Eun

AU - Hoang, Ngoc Ha

AU - Kang, Jin Kook

AU - Lim, Chaemin

AU - Kim, Dong Shik

AU - Lee, Eun Seong

AU - Youn, Yu Seok

AU - Choi, Han Gon

AU - Han, Hyo Kyung

AU - Weon, Kwon Yeon

AU - Oh, Kyung Taek

PY - 2018

Y1 - 2018

N2 - Docetaxel (DTX)-loaded polymeric micelles (DTBM) were formulated using the triblock copolymer, poly(ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG), to comprehensively study their pharmaceutical application as anticancer nanomedicine. DTBM showed a stable formulation of anticancer nanomedicine that could be reconstituted after lyophilization (DTBM-R) in the presence of PEG 2000 and D-mannitol (Man) as surfactant and protectant, respectively. DTBM-R showed a particle size less than 150nm and greater than 90% of DTX recovery after reconstitution. The robustly formed micelles might minimize systemic toxicity due to their sustained drug release and also maximize antitumor efficacy through increased accumulation and release of DTX from the micelles. From the pharmaceutical development point of view, DTBM-R showing successful reconstitution could be considered as a potent nanomedicine for tumor treatment.

AB - Docetaxel (DTX)-loaded polymeric micelles (DTBM) were formulated using the triblock copolymer, poly(ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG), to comprehensively study their pharmaceutical application as anticancer nanomedicine. DTBM showed a stable formulation of anticancer nanomedicine that could be reconstituted after lyophilization (DTBM-R) in the presence of PEG 2000 and D-mannitol (Man) as surfactant and protectant, respectively. DTBM-R showed a particle size less than 150nm and greater than 90% of DTX recovery after reconstitution. The robustly formed micelles might minimize systemic toxicity due to their sustained drug release and also maximize antitumor efficacy through increased accumulation and release of DTX from the micelles. From the pharmaceutical development point of view, DTBM-R showing successful reconstitution could be considered as a potent nanomedicine for tumor treatment.

KW - Cancer

KW - Lyophilization

KW - Nanomedicine

KW - Polymeric micelle

KW - Reconstitution

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DO - 10.1080/10717544.2018.1477865

M3 - Article

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AN - SCOPUS:85053437559

SN - 1071-7544

VL - 25

SP - 1371

EP - 1380

JO - Drug Delivery

JF - Drug Delivery

IS - 1

ER -

Development of a docetaxel micellar formulation using poly(Ethylene glycol)–polylactide–poly(ethylene glycol) (PEG–PLA–PEG) with successful reconstitution for tumor targeted drug delivery

Abstract

Keywords

UN SDGs

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